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Gradient nanostructures for interfacing microfluidics and nanofluidics

Cao, Han ; Tegenfeldt, Jonas O. LU ; Austin, Robert H. and Chou, Stephen Y. (2002) In Applied Physics Letters 81(16). p.3058-3060
Abstract

It is difficult to introduce long genomic DNA molecules into nanometer scale fluidic channels directly from the macroscale world because of the steep entropic barrier caused by necessary stretching of the polymer. We present a very simple technique using optical lithography to fabricate continuous spatial gradient structures which smoothly narrow the cross section of a volume from the micron to the nanometer length scale, greatly reducing the local entropic barrier to nanochannel entry. This technique, diffraction gradient lithography, can be very valuable for the fabrication of micro/nano total analysis systems.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
in
Applied Physics Letters
volume
81
issue
16
pages
3 pages
publisher
American Institute of Physics (AIP)
external identifiers
  • scopus:79956006132
ISSN
0003-6951
DOI
10.1063/1.1515115
language
English
LU publication?
yes
id
24091303-d541-4093-aac4-ef6f050ff0a6
date added to LUP
2018-10-20 10:40:17
date last changed
2020-12-29 01:28:51
@article{24091303-d541-4093-aac4-ef6f050ff0a6,
  abstract     = {<p>It is difficult to introduce long genomic DNA molecules into nanometer scale fluidic channels directly from the macroscale world because of the steep entropic barrier caused by necessary stretching of the polymer. We present a very simple technique using optical lithography to fabricate continuous spatial gradient structures which smoothly narrow the cross section of a volume from the micron to the nanometer length scale, greatly reducing the local entropic barrier to nanochannel entry. This technique, diffraction gradient lithography, can be very valuable for the fabrication of micro/nano total analysis systems.</p>},
  author       = {Cao, Han and Tegenfeldt, Jonas O. and Austin, Robert H. and Chou, Stephen Y.},
  issn         = {0003-6951},
  language     = {eng},
  month        = {10},
  number       = {16},
  pages        = {3058--3060},
  publisher    = {American Institute of Physics (AIP)},
  series       = {Applied Physics Letters},
  title        = {Gradient nanostructures for interfacing microfluidics and nanofluidics},
  url          = {http://dx.doi.org/10.1063/1.1515115},
  doi          = {10.1063/1.1515115},
  volume       = {81},
  year         = {2002},
}