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Early life low-level cadmium exposure is positively associated with increased oxidative stress

Kippler, Maria; Hossain, Mohammad Bakhtiar; Lindh, Christian LU ; Moore, Sophie E.; Kabir, Iqbal; Vahter, Marie and Broberg Palmgren, Karin LU (2012) In Environmental Research 112. p.164-170
Abstract
Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a recognized marker of oxidative DNA damage, in relation to Cd exposure in 96 predominantly breast-fed infants (11-17 weeks of age) in rural Bangladesh. Urinary 8-oxodG was measured using liquid chromatography tandem mass spectrometry and Cd in urine and breast milk by inductively coupled plasma mass spectrometry. Median concentration of 8-oxodG was 3.9 nmol/L, urinary Cd 0.30 mu g/L, and breast-milk... (More)
Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a recognized marker of oxidative DNA damage, in relation to Cd exposure in 96 predominantly breast-fed infants (11-17 weeks of age) in rural Bangladesh. Urinary 8-oxodG was measured using liquid chromatography tandem mass spectrometry and Cd in urine and breast milk by inductively coupled plasma mass spectrometry. Median concentration of 8-oxodG was 3.9 nmol/L, urinary Cd 0.30 mu g/L, and breast-milk Cd 0.13 mu g/L. In linear regression analyses, urinary 8-oxodG was positively associated with Cd in both urine (p=0.00067) and breast milk (p=0.0021), and negatively associated with body weight (kg: p=0.0041). Adjustment for age, body weight, socio-economic status, urinary arsenic, as well as magnesium, calcium, and copper in breast milk did not change the association between Cd exposure and urinary 8-oxodG. These findings suggest that early-life low-level exposure to Cd via breast milk induces oxidative stress. Further studies are warranted to elucidate whether this oxidative stress is associated with impaired child health and development. (C) 2011 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
8-oxodG, DNA damage, Infant, Cadmium, Breast-feeding
in
Environmental Research
volume
112
pages
164 - 170
publisher
Elsevier
external identifiers
  • wos:000299804800021
  • scopus:84856211031
ISSN
1096-0953
DOI
10.1016/j.envres.2011.11.012
language
English
LU publication?
yes
id
3ab95f1c-c8fe-49dc-8c56-36bd824bca18 (old id 2409705)
date added to LUP
2012-04-02 09:17:50
date last changed
2017-08-27 03:25:56
@article{3ab95f1c-c8fe-49dc-8c56-36bd824bca18,
  abstract     = {Environmental exposure to cadmium (Cd) is known to induce oxidative stress, a state of imbalance between the production of reactive oxygen species (ROS) and the ability to detoxify them, in adults. However, data are lacking on potential effects in early-life. We evaluated urinary concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a recognized marker of oxidative DNA damage, in relation to Cd exposure in 96 predominantly breast-fed infants (11-17 weeks of age) in rural Bangladesh. Urinary 8-oxodG was measured using liquid chromatography tandem mass spectrometry and Cd in urine and breast milk by inductively coupled plasma mass spectrometry. Median concentration of 8-oxodG was 3.9 nmol/L, urinary Cd 0.30 mu g/L, and breast-milk Cd 0.13 mu g/L. In linear regression analyses, urinary 8-oxodG was positively associated with Cd in both urine (p=0.00067) and breast milk (p=0.0021), and negatively associated with body weight (kg: p=0.0041). Adjustment for age, body weight, socio-economic status, urinary arsenic, as well as magnesium, calcium, and copper in breast milk did not change the association between Cd exposure and urinary 8-oxodG. These findings suggest that early-life low-level exposure to Cd via breast milk induces oxidative stress. Further studies are warranted to elucidate whether this oxidative stress is associated with impaired child health and development. (C) 2011 Elsevier Inc. All rights reserved.},
  author       = {Kippler, Maria and Hossain, Mohammad Bakhtiar and Lindh, Christian and Moore, Sophie E. and Kabir, Iqbal and Vahter, Marie and Broberg Palmgren, Karin},
  issn         = {1096-0953},
  keyword      = {8-oxodG,DNA damage,Infant,Cadmium,Breast-feeding},
  language     = {eng},
  pages        = {164--170},
  publisher    = {Elsevier},
  series       = {Environmental Research},
  title        = {Early life low-level cadmium exposure is positively associated with increased oxidative stress},
  url          = {http://dx.doi.org/10.1016/j.envres.2011.11.012},
  volume       = {112},
  year         = {2012},
}