Ancestral susceptibility to colorectal cancer
(2012) In Mutagenesis 27(2). p.197-204- Abstract
- Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be... (More)
- Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2409774
- author
- Huhn, Stefanie ; Pardini, Barbara ; Naccarati, Alessio ; Vodicka, Pavel ; Hemminki, Kari LU and Försti, Asta LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Mutagenesis
- volume
- 27
- issue
- 2
- pages
- 197 - 204
- publisher
- Oxford University Press
- external identifiers
-
- wos:000300040200008
- scopus:84856906091
- pmid:22294767
- ISSN
- 0267-8357
- DOI
- 10.1093/mutage/ger061
- language
- English
- LU publication?
- yes
- id
- b49113d5-716a-415f-9620-4e70dcfcb9be (old id 2409774)
- date added to LUP
- 2016-04-01 14:29:41
- date last changed
- 2022-01-28 00:51:57
@article{b49113d5-716a-415f-9620-4e70dcfcb9be,
abstract = {{Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease.}},
author = {{Huhn, Stefanie and Pardini, Barbara and Naccarati, Alessio and Vodicka, Pavel and Hemminki, Kari and Försti, Asta}},
issn = {{0267-8357}},
language = {{eng}},
number = {{2}},
pages = {{197--204}},
publisher = {{Oxford University Press}},
series = {{Mutagenesis}},
title = {{Ancestral susceptibility to colorectal cancer}},
url = {{http://dx.doi.org/10.1093/mutage/ger061}},
doi = {{10.1093/mutage/ger061}},
volume = {{27}},
year = {{2012}},
}