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Ancestral susceptibility to colorectal cancer

Huhn, Stefanie; Pardini, Barbara; Naccarati, Alessio; Vodicka, Pavel; Hemminki, Kari LU and Försti, Asta LU (2012) In Mutagenesis 27(2). p.197-204
Abstract
Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be... (More)
Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Mutagenesis
volume
27
issue
2
pages
197 - 204
publisher
Oxford University Press
external identifiers
  • wos:000300040200008
  • scopus:84856906091
ISSN
0267-8357
DOI
10.1093/mutage/ger061
language
English
LU publication?
yes
id
b49113d5-716a-415f-9620-4e70dcfcb9be (old id 2409774)
date added to LUP
2012-04-02 09:32:25
date last changed
2017-01-01 06:16:24
@article{b49113d5-716a-415f-9620-4e70dcfcb9be,
  abstract     = {Every year, approximately 1 million new colorectal cancer (CRC) cases are diagnosed and about half a million people worldwide die due to this cancer. Known differences in CRC incidence rates are mainly attributed to differences in diet and other environmental factors represented, among others, by nutrition-related complex diseases (e.g. obesity and diabetes mellitus type II). Within the last years, it has become evident that environmental risk factors can be complemented by a genetic component when considering the risk of CRC. For example, a number of polymorphisms are known to be associated with an increased risk of obesity and obesity is a risk factor for CRC. Several studies have shown that the 'ancestral-susceptibility model' can be reasonably applied to nutrition-related complex diseases such as obesity. The work in hand shortly discusses whether the ancestral-susceptibility model can also be applied to CRC as a nutrition-related complex disease.},
  author       = {Huhn, Stefanie and Pardini, Barbara and Naccarati, Alessio and Vodicka, Pavel and Hemminki, Kari and Försti, Asta},
  issn         = {0267-8357},
  language     = {eng},
  number       = {2},
  pages        = {197--204},
  publisher    = {Oxford University Press},
  series       = {Mutagenesis},
  title        = {Ancestral susceptibility to colorectal cancer},
  url          = {http://dx.doi.org/10.1093/mutage/ger061},
  volume       = {27},
  year         = {2012},
}