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Nonlinear compartmental model of F-18-choline

Tavola, Federico; Janzen, Tilman; Giussani, Augusto; Facchinetti, Danya; Veronese, Ivan; Uusijärvi, Helena LU ; Mattsson, Sören LU ; Hoeschen, Christoph and Cantone, Marie Claire (2012) In Nuclear Medicine and Biology 39(2). p.261-268
Abstract
Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood... (More)
Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood and urinary excretion. The linear model tended to overestimate systematically the activity in the liver and in the kidney compartments in the first 20 min post-administration. A nonlinear process of kinetic saturation was considered, according to the typical Michaelis-Menten kinetics. Therefore nonlinear equations were added to describe the flux of 18F-choline from blood to liver and from blood to kidneys. The nonlinear model showed a tendency for improvement in the description of the activity in liver and kidneys, but not for the urine. Conclusions: The simple linear model presented is not able to properly describe the biokinetics of 18F-choline as measured in prostatic cancer patients. The introduction of nonlinear kinetics, although based on physiologically plausible assumptions, resulted in nonsignificant improvements of the model predictive power. (C) 2012 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
F-18-Choline, PET, Nonlinear model, Kinetic saturation, Prostate, carcinoma
in
Nuclear Medicine and Biology
volume
39
issue
2
pages
261 - 268
publisher
Elsevier
external identifiers
  • wos:000300121300010
  • scopus:84856328287
ISSN
1872-9614
DOI
10.1016/j.nucmedbio.2011.09.002
language
English
LU publication?
yes
id
43314d69-74b3-4d4a-b189-e441bc0f8df5 (old id 2409884)
date added to LUP
2012-04-02 09:32:33
date last changed
2017-01-01 04:01:52
@article{43314d69-74b3-4d4a-b189-e441bc0f8df5,
  abstract     = {Introduction: This work develops a compartmental model of F-18-choline in order to evaluate its biokinetics and so to describe the temporal variation of the radiopharmaceuticals' uptake in and clearance from organs and tissues. Methods: Ten patients were considered in this study. A commercially available tool for compartmental analysis (SAAM II) was used to model the values of activity concentrations in organs and tissues obtained from PET images or from measurements of collected blood and urine samples. Results: A linear compartmental model of the biokinetics of the radiopharmaceutical was initially developed. It features a central compartment (blood) exchanging with organs. The structure describes explicitly liver, kidneys, spleen, blood and urinary excretion. The linear model tended to overestimate systematically the activity in the liver and in the kidney compartments in the first 20 min post-administration. A nonlinear process of kinetic saturation was considered, according to the typical Michaelis-Menten kinetics. Therefore nonlinear equations were added to describe the flux of 18F-choline from blood to liver and from blood to kidneys. The nonlinear model showed a tendency for improvement in the description of the activity in liver and kidneys, but not for the urine. Conclusions: The simple linear model presented is not able to properly describe the biokinetics of 18F-choline as measured in prostatic cancer patients. The introduction of nonlinear kinetics, although based on physiologically plausible assumptions, resulted in nonsignificant improvements of the model predictive power. (C) 2012 Elsevier Inc. All rights reserved.},
  author       = {Tavola, Federico and Janzen, Tilman and Giussani, Augusto and Facchinetti, Danya and Veronese, Ivan and Uusijärvi, Helena and Mattsson, Sören and Hoeschen, Christoph and Cantone, Marie Claire},
  issn         = {1872-9614},
  keyword      = {F-18-Choline,PET,Nonlinear model,Kinetic saturation,Prostate,carcinoma},
  language     = {eng},
  number       = {2},
  pages        = {261--268},
  publisher    = {Elsevier},
  series       = {Nuclear Medicine and Biology},
  title        = {Nonlinear compartmental model of F-18-choline},
  url          = {http://dx.doi.org/10.1016/j.nucmedbio.2011.09.002},
  volume       = {39},
  year         = {2012},
}