Survival of mammalian cells exposed to ultrahigh dose rates from a laser-produced plasma x-ray source
(1999) In Radiology 213(3). p.860-865- Abstract
- PURPOSE: To determine whether intense laser-produced x rays have an increased radiation hazard. MATERIALS AND METHODS: Mammalian cells were exposed to x rays from a laser-produced plasma that produced ultrahigh peak absorbed dose rates, up to a factor of 10(10) higher than those produced by conventional x rays used in imaging. The cell survival was studied as a function of the absorbed dose. The survival of mammalian cells exposed to high peak absorbed dose rates with laser-produced x rays was compared with the survival of cells exposed to standard absorbed dose rates with conventional x-ray sources. Comparative survival studies were performed by using a conventional x-ray tube and a cobalt 60 source. The absorbed doses in the irradiation... (More)
- PURPOSE: To determine whether intense laser-produced x rays have an increased radiation hazard. MATERIALS AND METHODS: Mammalian cells were exposed to x rays from a laser-produced plasma that produced ultrahigh peak absorbed dose rates, up to a factor of 10(10) higher than those produced by conventional x rays used in imaging. The cell survival was studied as a function of the absorbed dose. The survival of mammalian cells exposed to high peak absorbed dose rates with laser-produced x rays was compared with the survival of cells exposed to standard absorbed dose rates with conventional x-ray sources. Comparative survival studies were performed by using a conventional x-ray tube and a cobalt 60 source. The absorbed doses in the irradiation field were measured with thermoluminescent dosimeters. RESULTS: Cell survival following irradiation by filtered, laser-produced x rays with a high dose rate was not markedly different from the survival following irradiation by conventional sources. There was, however, a notable difference between the survival after exposure to filtered, laser-produced x rays and the survival after exposure to unfiltered laser-produced x rays. CONCLUSION: Exposure to filtered, laser-produced x rays with a high dose rate does not lead to increased harm to mammalian cells exposed in vitro compared with the harm from exposure to x rays from conventional sources, which indicates that the use of high-power laser facilities for medical imaging is justified (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1116125
- author
- Tillman, Carl ; Grafström, Gustav LU ; Jonsson, Ann-Charlotte ; Jönsson, Bo-Anders LU ; Mercer, Ian ; Mattsson, Sören LU ; Strand, Sven-Erik LU and Svanberg, Sune LU
- organization
- publishing date
- 1999
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Radiology
- volume
- 213
- issue
- 3
- pages
- 860 - 865
- publisher
- Radiological Society of North America
- external identifiers
-
- scopus:0344672620
- ISSN
- 1527-1315
- language
- English
- LU publication?
- yes
- id
- 242270a1-cc66-4083-b1db-9cd51fa0f299 (old id 1116125)
- alternative location
- http://radiology.rsnajnls.org/cgi/content/full/213/3/860
- date added to LUP
- 2016-04-01 15:44:22
- date last changed
- 2022-03-30 02:46:55
@article{242270a1-cc66-4083-b1db-9cd51fa0f299,
abstract = {{PURPOSE: To determine whether intense laser-produced x rays have an increased radiation hazard. MATERIALS AND METHODS: Mammalian cells were exposed to x rays from a laser-produced plasma that produced ultrahigh peak absorbed dose rates, up to a factor of 10(10) higher than those produced by conventional x rays used in imaging. The cell survival was studied as a function of the absorbed dose. The survival of mammalian cells exposed to high peak absorbed dose rates with laser-produced x rays was compared with the survival of cells exposed to standard absorbed dose rates with conventional x-ray sources. Comparative survival studies were performed by using a conventional x-ray tube and a cobalt 60 source. The absorbed doses in the irradiation field were measured with thermoluminescent dosimeters. RESULTS: Cell survival following irradiation by filtered, laser-produced x rays with a high dose rate was not markedly different from the survival following irradiation by conventional sources. There was, however, a notable difference between the survival after exposure to filtered, laser-produced x rays and the survival after exposure to unfiltered laser-produced x rays. CONCLUSION: Exposure to filtered, laser-produced x rays with a high dose rate does not lead to increased harm to mammalian cells exposed in vitro compared with the harm from exposure to x rays from conventional sources, which indicates that the use of high-power laser facilities for medical imaging is justified}},
author = {{Tillman, Carl and Grafström, Gustav and Jonsson, Ann-Charlotte and Jönsson, Bo-Anders and Mercer, Ian and Mattsson, Sören and Strand, Sven-Erik and Svanberg, Sune}},
issn = {{1527-1315}},
language = {{eng}},
number = {{3}},
pages = {{860--865}},
publisher = {{Radiological Society of North America}},
series = {{Radiology}},
title = {{Survival of mammalian cells exposed to ultrahigh dose rates from a laser-produced plasma x-ray source}},
url = {{http://radiology.rsnajnls.org/cgi/content/full/213/3/860}},
volume = {{213}},
year = {{1999}},
}