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Pro- and synbiotics to prevent sepsis in major surgery and severe emergencies.

Bengmark, Stig LU (2012) In Nutrients 4(2). p.91-111
Abstract
Septic morbidity associated with advanced surgical and medical treatments is unacceptably high, and so is the incidence of complications occurring in connection with acute emergencies such as severe trauma and severe acute pancreatitis. Only considering the US, it will annually affect approximately (app) 300 million (mill) of a population of almost one million inhabitants and cause the death of more than 200,000 patients, making sepsis the tenth most common cause of death in the US. Two major factors affect this, the lifestyle-associated increased weakness of the immune defense systems, but more than this the artificial environment associated with modern treatments such as mechanical ventilation, use of tubes, drains, intravascular lines,... (More)
Septic morbidity associated with advanced surgical and medical treatments is unacceptably high, and so is the incidence of complications occurring in connection with acute emergencies such as severe trauma and severe acute pancreatitis. Only considering the US, it will annually affect approximately (app) 300 million (mill) of a population of almost one million inhabitants and cause the death of more than 200,000 patients, making sepsis the tenth most common cause of death in the US. Two major factors affect this, the lifestyle-associated increased weakness of the immune defense systems, but more than this the artificial environment associated with modern treatments such as mechanical ventilation, use of tubes, drains, intravascular lines, artificial nutrition and extensive use of synthetic chemical drugs, methods all known to reduce or eliminate the human microbiota and impair immune functions and increase systemic inflammation. Attempts to recondition the gut by the supply of microorganisms have sometimes shown remarkably good results, but too often failed. Many factors contribute to the lack of success: unsuitable choice of probiotic species, too low dose, but most importantly, this bio-ecological treatment has never been given the opportunity to be tried as an alternative treatment. Instead it has most often been applied as complementary to all the other treatments mentioned above, including antibiotic treatment. The supplemented lactic acid bacteria have most often been killed already before they have reached their targeted organs. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrients
volume
4
issue
2
pages
91 - 111
publisher
MDPI AG
external identifiers
  • wos:000300718900003
  • pmid:22413064
  • scopus:84857663981
ISSN
2072-6643
DOI
10.3390/nu4020091
language
English
LU publication?
yes
id
40feec03-d194-43ef-bd87-f55077e3c5b4 (old id 2431887)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22413064?dopt=Abstract
date added to LUP
2012-04-03 10:34:40
date last changed
2017-02-12 03:46:01
@article{40feec03-d194-43ef-bd87-f55077e3c5b4,
  abstract     = {Septic morbidity associated with advanced surgical and medical treatments is unacceptably high, and so is the incidence of complications occurring in connection with acute emergencies such as severe trauma and severe acute pancreatitis. Only considering the US, it will annually affect approximately (app) 300 million (mill) of a population of almost one million inhabitants and cause the death of more than 200,000 patients, making sepsis the tenth most common cause of death in the US. Two major factors affect this, the lifestyle-associated increased weakness of the immune defense systems, but more than this the artificial environment associated with modern treatments such as mechanical ventilation, use of tubes, drains, intravascular lines, artificial nutrition and extensive use of synthetic chemical drugs, methods all known to reduce or eliminate the human microbiota and impair immune functions and increase systemic inflammation. Attempts to recondition the gut by the supply of microorganisms have sometimes shown remarkably good results, but too often failed. Many factors contribute to the lack of success: unsuitable choice of probiotic species, too low dose, but most importantly, this bio-ecological treatment has never been given the opportunity to be tried as an alternative treatment. Instead it has most often been applied as complementary to all the other treatments mentioned above, including antibiotic treatment. The supplemented lactic acid bacteria have most often been killed already before they have reached their targeted organs.},
  author       = {Bengmark, Stig},
  issn         = {2072-6643},
  language     = {eng},
  number       = {2},
  pages        = {91--111},
  publisher    = {MDPI AG},
  series       = {Nutrients},
  title        = {Pro- and synbiotics to prevent sepsis in major surgery and severe emergencies.},
  url          = {http://dx.doi.org/10.3390/nu4020091},
  volume       = {4},
  year         = {2012},
}