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Influence of dexamethasone and alpha-ketoglutarate on growth and development of the skeletal system of pigs

Sliwa, E; Wawrzyniak-Gacek, A; Tatara, MR; Kowalik, S; Luszczewska-Sierakowska, I; Krupsli, W; Majcher, P; Pierzynowski, Stefan LU and Studzinski, T (2005) In Medycyna Weterynaryjna 61(5). p.526-531
Abstract
The aim of the study was to establish the influence of dexamethasone and/or alpha-ketoglutarate (AKG) on the growth, mineralization, geometric and mechanical properties of ribs as a methodological model. The experiment was conducted during the final 24 days of prenatal life and first 14 days of neonatal life. The volumetric bone density of the trabecular and cortical bone was determined separately using the quantitative computed tomography (QCT) method and Somatom AR. T - Siemens apparatus. The mechanical properties were determined using the three-point bending test according to the method by Ferretti et al. The obtained results indicate that maternal administration of dexamethasone increased volumetric mineral density, although the... (More)
The aim of the study was to establish the influence of dexamethasone and/or alpha-ketoglutarate (AKG) on the growth, mineralization, geometric and mechanical properties of ribs as a methodological model. The experiment was conducted during the final 24 days of prenatal life and first 14 days of neonatal life. The volumetric bone density of the trabecular and cortical bone was determined separately using the quantitative computed tomography (QCT) method and Somatom AR. T - Siemens apparatus. The mechanical properties were determined using the three-point bending test according to the method by Ferretti et al. The obtained results indicate that maternal administration of dexamethasone increased volumetric mineral density, although the mechanical parameters had lower values. Prenatal administration of AKG decreased all the geometric and mechanical parameters of the investigated ribs. The results obtained during the administration of the compound in neonatal life were the opposite of the prenatal results. Dexamethasone and AKG given together had the same influence on mineralization and other properties AND increasing their values during prenatal and neonatal life. This model of administrating dexamethasone and AKG maternally during prenatal life with the intention of provoking structural growth of the skeleton may be useful in further elucidating some biological and pharmacological factors on bone formation in prenatal life. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dexamethasone, AKG, ribs, prenatal life, piglets
in
Medycyna Weterynaryjna
volume
61
issue
5
pages
526 - 531
publisher
POLISH SOC VETERINARY SCIENCES EDITORIAL OFFICE
external identifiers
  • wos:000228821600011
  • scopus:19444384182
ISSN
0025-8628
language
Polish
LU publication?
yes
id
4bc4d658-3663-43e9-9cde-3c4b1bafba46 (old id 243207)
date added to LUP
2007-08-15 15:46:15
date last changed
2017-01-01 07:18:15
@article{4bc4d658-3663-43e9-9cde-3c4b1bafba46,
  abstract     = {The aim of the study was to establish the influence of dexamethasone and/or alpha-ketoglutarate (AKG) on the growth, mineralization, geometric and mechanical properties of ribs as a methodological model. The experiment was conducted during the final 24 days of prenatal life and first 14 days of neonatal life. The volumetric bone density of the trabecular and cortical bone was determined separately using the quantitative computed tomography (QCT) method and Somatom AR. T - Siemens apparatus. The mechanical properties were determined using the three-point bending test according to the method by Ferretti et al. The obtained results indicate that maternal administration of dexamethasone increased volumetric mineral density, although the mechanical parameters had lower values. Prenatal administration of AKG decreased all the geometric and mechanical parameters of the investigated ribs. The results obtained during the administration of the compound in neonatal life were the opposite of the prenatal results. Dexamethasone and AKG given together had the same influence on mineralization and other properties AND increasing their values during prenatal and neonatal life. This model of administrating dexamethasone and AKG maternally during prenatal life with the intention of provoking structural growth of the skeleton may be useful in further elucidating some biological and pharmacological factors on bone formation in prenatal life.},
  author       = {Sliwa, E and Wawrzyniak-Gacek, A and Tatara, MR and Kowalik, S and Luszczewska-Sierakowska, I and Krupsli, W and Majcher, P and Pierzynowski, Stefan and Studzinski, T},
  issn         = {0025-8628},
  keyword      = {dexamethasone,AKG,ribs,prenatal life,piglets},
  language     = {pol},
  number       = {5},
  pages        = {526--531},
  publisher    = {POLISH SOC VETERINARY SCIENCES EDITORIAL OFFICE},
  series       = {Medycyna Weterynaryjna},
  title        = {Influence of dexamethasone and alpha-ketoglutarate on growth and development of the skeletal system of pigs},
  volume       = {61},
  year         = {2005},
}