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Increased Urine IgM and IgG(2) Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes.

Torffvit, Ole LU ; Kalani, Majid; Apelqvist, Jan LU ; Eliasson, Björn; Eriksson, Jan W; Brismar, Kerstin and Jörneskog, Gun (2012) In Biochemistry Research International 2012.
Abstract
Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG(2) indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P < 0.001) and serum IGFBP-1 (P < 0.05) while no significant effects were seen in any of the other studied parameters. In... (More)
Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG(2) indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P < 0.001) and serum IGFBP-1 (P < 0.05) while no significant effects were seen in any of the other studied parameters. In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG(2) despite significantly increased glycosaminoglycans in urine. Elevated urinary levels of IgM and IgG(2) might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
in
Biochemistry Research International
volume
2012
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:22400116
  • scopus:84858300929
ISSN
2090-2247
DOI
10.1155/2012/480529
language
English
LU publication?
yes
id
ceaf5c21-9406-4692-ba33-21abec3e217d (old id 2432139)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22400116?dopt=Abstract
date added to LUP
2012-04-03 09:24:23
date last changed
2017-01-01 03:26:16
@article{ceaf5c21-9406-4692-ba33-21abec3e217d,
  abstract     = {Fifty-four type 2 diabetic patients with neuroischemic foot ulcers were randomised to treatment with 5000 IU of dalteparin, (n = 28), or physiological saline, (n = 26), once daily until ulcer healing or for a maximum of 6 months. Thirty-three patients had normo-, 15 micro-, and 6 macroalbuminuria. The urinary levels of IgM and IgG(2) were elevated in 47 and 50 patients, respectively. Elevated urinary levels of IgM and IgG(2) indicate decreased glomerular size selectivity. Urine IgM levels were associated with IGF-1/IGFBP-1 and IGFBP-1 levels. Dalteparin treatment increased urinary levels of glycosaminoglycans (P &lt; 0.001) and serum IGFBP-1 (P &lt; 0.05) while no significant effects were seen in any of the other studied parameters. In conclusion, dalteparin therapy in patients with type 2 diabetes had no effects on urinary levels of albumin, IgM, or IgG(2) despite significantly increased glycosaminoglycans in urine. Elevated urinary levels of IgM and IgG(2) might be more sensitive markers of renal disease than albuminuria in patients with type 2 diabetes and antihypertensive therapy.},
  articleno    = {480529},
  author       = {Torffvit, Ole and Kalani, Majid and Apelqvist, Jan and Eliasson, Björn and Eriksson, Jan W and Brismar, Kerstin and Jörneskog, Gun},
  issn         = {2090-2247},
  language     = {eng},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Biochemistry Research International},
  title        = {Increased Urine IgM and IgG(2) Levels, Indicating Decreased Glomerular Size Selectivity, Are Not Affected by Dalteparin Therapy in Patients with Type 2 Diabetes.},
  url          = {http://dx.doi.org/10.1155/2012/480529},
  volume       = {2012},
  year         = {2012},
}