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Cetuximab sensitivity associated with oxaliplatin resistance in colorectal cancer.

Ekblad, Lars LU and Johnsson, Anders LU (2012) In Anticancer Research 32(3). p.783-786
Abstract
BACKGROUND:

Clinical studies have suggested that the epidermal growth factor receptor (EGFR)-inhibiting antibody cetuximab may have better effect in the third-line treatment of metastatic colorectal cancer, after failure of standard chemotherapy including oxaliplatin, compared to using it up-front in the first line. The reason behind this suggestion is unclear.



MATERIALS AND METHODS:

The effect of cetuximab on cell growth was investigated in five isogenic colon cancer cell lines with increasing level of acquired oxaliplatin resistance. The expression of EGFR and the activity of down-stream signalling molecules were measured by western blot analyses.



RESULTS:

A marked increase... (More)
BACKGROUND:

Clinical studies have suggested that the epidermal growth factor receptor (EGFR)-inhibiting antibody cetuximab may have better effect in the third-line treatment of metastatic colorectal cancer, after failure of standard chemotherapy including oxaliplatin, compared to using it up-front in the first line. The reason behind this suggestion is unclear.



MATERIALS AND METHODS:

The effect of cetuximab on cell growth was investigated in five isogenic colon cancer cell lines with increasing level of acquired oxaliplatin resistance. The expression of EGFR and the activity of down-stream signalling molecules were measured by western blot analyses.



RESULTS:

A marked increase in sensitivity to cetuximab, accompanied by an up-regulation of EGFR, was observed in the oxaliplatin-resistant cell lines.



CONCLUSION:

The connection between oxaliplatin resistance and cetuximab sensitivity has not been previously reported in the literature. Such a connection could be of clinical importance and constitutes a substantial an argument for saving cetuximab until later treatment lines, when the tumours have become chemotherapy resistant. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Anticancer Research
volume
32
issue
3
pages
783 - 786
publisher
International Institute of Cancer Research
external identifiers
  • wos:000301619200011
  • pmid:22399593
  • scopus:84858786876
ISSN
1791-7530
language
English
LU publication?
yes
id
ecf6a3fa-85c4-48cf-8c0a-0de94c0297f3 (old id 2432149)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22399593?dopt=Abstract
date added to LUP
2012-04-03 09:26:40
date last changed
2017-01-29 04:14:20
@article{ecf6a3fa-85c4-48cf-8c0a-0de94c0297f3,
  abstract     = {BACKGROUND:<br/><br>
Clinical studies have suggested that the epidermal growth factor receptor (EGFR)-inhibiting antibody cetuximab may have better effect in the third-line treatment of metastatic colorectal cancer, after failure of standard chemotherapy including oxaliplatin, compared to using it up-front in the first line. The reason behind this suggestion is unclear.<br/><br>
<br/><br>
MATERIALS AND METHODS:<br/><br>
The effect of cetuximab on cell growth was investigated in five isogenic colon cancer cell lines with increasing level of acquired oxaliplatin resistance. The expression of EGFR and the activity of down-stream signalling molecules were measured by western blot analyses.<br/><br>
<br/><br>
RESULTS:<br/><br>
A marked increase in sensitivity to cetuximab, accompanied by an up-regulation of EGFR, was observed in the oxaliplatin-resistant cell lines.<br/><br>
<br/><br>
CONCLUSION:<br/><br>
The connection between oxaliplatin resistance and cetuximab sensitivity has not been previously reported in the literature. Such a connection could be of clinical importance and constitutes a substantial an argument for saving cetuximab until later treatment lines, when the tumours have become chemotherapy resistant.},
  author       = {Ekblad, Lars and Johnsson, Anders},
  issn         = {1791-7530},
  language     = {eng},
  number       = {3},
  pages        = {783--786},
  publisher    = {International Institute of Cancer Research},
  series       = {Anticancer Research},
  title        = {Cetuximab sensitivity associated with oxaliplatin resistance in colorectal cancer.},
  volume       = {32},
  year         = {2012},
}