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How to manage invasive procedures in children with haemophilia.

Ljung, Rolf LU and Knobe, Karin LU (2012) In British Journal of Haematology 157(5). p.519-528
Abstract
Invasive procedures can be performed safely in children with haemophilia due to the availability of factor VIII/IX for patients without inhibitors. Most guidelines are based on the experiences in adults, but still there is no established consensus on the optimal factor levels or duration of replacement therapy for adults undergoing surgery. Few publications have focused on surgery in children with haemophilia. Children who have developed inhibitors to factor VIII/IX have to be treated with bypassing agents and constitute a group at higher risk for bleeding complications during surgery. The aim of this review is to summarize the experiences and opinions in the literature on replacement treatment of children with haemophilia, with and... (More)
Invasive procedures can be performed safely in children with haemophilia due to the availability of factor VIII/IX for patients without inhibitors. Most guidelines are based on the experiences in adults, but still there is no established consensus on the optimal factor levels or duration of replacement therapy for adults undergoing surgery. Few publications have focused on surgery in children with haemophilia. Children who have developed inhibitors to factor VIII/IX have to be treated with bypassing agents and constitute a group at higher risk for bleeding complications during surgery. The aim of this review is to summarize the experiences and opinions in the literature on replacement treatment of children with haemophilia, with and without inhibitors, during and after surgery, with a focus on the most prevalent clinical situations. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
British Journal of Haematology
volume
157
issue
5
pages
519 - 528
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000303856400003
  • pmid:22390160
  • scopus:84860840887
ISSN
0007-1048
DOI
10.1111/j.1365-2141.2012.09089.x
language
English
LU publication?
yes
id
3fa79be4-16c3-439e-b642-6c5a286541c2 (old id 2432268)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22390160?dopt=Abstract
date added to LUP
2012-04-03 08:47:43
date last changed
2017-11-12 04:06:52
@article{3fa79be4-16c3-439e-b642-6c5a286541c2,
  abstract     = {Invasive procedures can be performed safely in children with haemophilia due to the availability of factor VIII/IX for patients without inhibitors. Most guidelines are based on the experiences in adults, but still there is no established consensus on the optimal factor levels or duration of replacement therapy for adults undergoing surgery. Few publications have focused on surgery in children with haemophilia. Children who have developed inhibitors to factor VIII/IX have to be treated with bypassing agents and constitute a group at higher risk for bleeding complications during surgery. The aim of this review is to summarize the experiences and opinions in the literature on replacement treatment of children with haemophilia, with and without inhibitors, during and after surgery, with a focus on the most prevalent clinical situations.},
  author       = {Ljung, Rolf and Knobe, Karin},
  issn         = {0007-1048},
  language     = {eng},
  number       = {5},
  pages        = {519--528},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {British Journal of Haematology},
  title        = {How to manage invasive procedures in children with haemophilia.},
  url          = {http://dx.doi.org/10.1111/j.1365-2141.2012.09089.x},
  volume       = {157},
  year         = {2012},
}