Advanced

A nationwide family study of pulmonary embolism: Identification of high risk families with increased risk of hospitalized and fatal pulmonary embolism.

Zöller, Bengt LU ; Li, Xinjun LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2012) In Thrombosis Research 130(2). p.178-182
Abstract
BACKGROUND: Family history is an important risk factor for deep venous thrombosis. However, few studies have determined the importance of family history of pulmonary embolism (PE).



OBJECTIVE: This nationwide study aimed to determine the familial risks of fatal and hospitalized PE.



METHODS: The Swedish Multi-Generation Register for subjects aged 0 to 76years old born since 1932 were linked to the Hospital Discharge Register and Cause of Death Register for the period 1964-2008. Standardized incidence ratios (SIRs) for first hospitalization or death (without previous hospitalization for PE) with a main diagnosis of PE were calculated for individuals whose parent or siblings were hospitalized with or... (More)
BACKGROUND: Family history is an important risk factor for deep venous thrombosis. However, few studies have determined the importance of family history of pulmonary embolism (PE).



OBJECTIVE: This nationwide study aimed to determine the familial risks of fatal and hospitalized PE.



METHODS: The Swedish Multi-Generation Register for subjects aged 0 to 76years old born since 1932 were linked to the Hospital Discharge Register and Cause of Death Register for the period 1964-2008. Standardized incidence ratios (SIRs) for first hospitalization or death (without previous hospitalization for PE) with a main diagnosis of PE were calculated for individuals whose parent or siblings were hospitalized with or died from PE, compared to those whose parent or siblings were not affected by PE.



RESULTS: A total of 20,860 individuals were hospitalized for PE and 862 died due to primary fatal PE (without previous hospitalization for PE). The familial SIR for individuals with one sibling with hospitalized PE was 2.49 (95% CI 1.62-3.83). The familial SIR for siblings with two affected probands was 114.29 (95% CI 56.57-223.95). The familial SIRs for individuals with a parent or sibling hospitalized for PE were significantly increased for fatal PE (1.76; 95% CI 1.38-2.21) and hospitalized PE (2.13; 95% CI 2.04-2.23). Spouses had low overall familial risk for PE (1.09; 95% CI, 1.03-1.14).



CONCLUSION: The high familial risk in multiplex sibling families suggests the existence of strong genetic risk factors for PE. Familial factors and possibly genetic factors are important risk factors for primary fatal pulmonary embolism. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Thrombosis Research
volume
130
issue
2
pages
178 - 182
external identifiers
  • wos:000306959500009
  • pmid:22386135
  • scopus:84864413291
ISSN
1879-2472
DOI
10.1016/j.thromres.2012.02.002
language
English
LU publication?
yes
id
0e2a221e-e87c-421f-81f6-52ee5c087553 (old id 2432279)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22386135?dopt=Abstract
date added to LUP
2012-04-03 08:27:00
date last changed
2017-04-16 04:21:12
@article{0e2a221e-e87c-421f-81f6-52ee5c087553,
  abstract     = {BACKGROUND: Family history is an important risk factor for deep venous thrombosis. However, few studies have determined the importance of family history of pulmonary embolism (PE). <br/><br>
<br/><br>
OBJECTIVE: This nationwide study aimed to determine the familial risks of fatal and hospitalized PE. <br/><br>
<br/><br>
METHODS: The Swedish Multi-Generation Register for subjects aged 0 to 76years old born since 1932 were linked to the Hospital Discharge Register and Cause of Death Register for the period 1964-2008. Standardized incidence ratios (SIRs) for first hospitalization or death (without previous hospitalization for PE) with a main diagnosis of PE were calculated for individuals whose parent or siblings were hospitalized with or died from PE, compared to those whose parent or siblings were not affected by PE. <br/><br>
<br/><br>
RESULTS: A total of 20,860 individuals were hospitalized for PE and 862 died due to primary fatal PE (without previous hospitalization for PE). The familial SIR for individuals with one sibling with hospitalized PE was 2.49 (95% CI 1.62-3.83). The familial SIR for siblings with two affected probands was 114.29 (95% CI 56.57-223.95). The familial SIRs for individuals with a parent or sibling hospitalized for PE were significantly increased for fatal PE (1.76; 95% CI 1.38-2.21) and hospitalized PE (2.13; 95% CI 2.04-2.23). Spouses had low overall familial risk for PE (1.09; 95% CI, 1.03-1.14). <br/><br>
<br/><br>
CONCLUSION: The high familial risk in multiplex sibling families suggests the existence of strong genetic risk factors for PE. Familial factors and possibly genetic factors are important risk factors for primary fatal pulmonary embolism.},
  author       = {Zöller, Bengt and Li, Xinjun and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1879-2472},
  language     = {eng},
  number       = {2},
  pages        = {178--182},
  series       = {Thrombosis Research},
  title        = {A nationwide family study of pulmonary embolism: Identification of high risk families with increased risk of hospitalized and fatal pulmonary embolism.},
  url          = {http://dx.doi.org/10.1016/j.thromres.2012.02.002},
  volume       = {130},
  year         = {2012},
}