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Acute myeloid leukemia in the real world: why population-based registries are needed.

Juliusson, Gunnar LU ; Lazarevic, Vladimir LU ; Hörstedt, Ann-sofi LU ; Hagberg, Oskar LU and Hoglund, Martin (2012) In Blood 119(17). p.3890-3899
Abstract
Population-based registries may provide data complementary to that from basic science and clinical intervention studies, all of which essential for establishing recommendations for the management of patients in the real world. The same quality criteria apply for the evidence-based label, and both high representation and good data quality are crucial in registry studies. Registries with high coverage of the target population reduce the impact of selection on outcome and the subsequent problem with extrapolating data to non-studied populations. Thus data, useful for clinical decision in situations not well covered by clinical studies, can be provided. The potential clinical impact of data from population-based studies is exemplified with... (More)
Population-based registries may provide data complementary to that from basic science and clinical intervention studies, all of which essential for establishing recommendations for the management of patients in the real world. The same quality criteria apply for the evidence-based label, and both high representation and good data quality are crucial in registry studies. Registries with high coverage of the target population reduce the impact of selection on outcome and the subsequent problem with extrapolating data to non-studied populations. Thus data, useful for clinical decision in situations not well covered by clinical studies, can be provided. The potential clinical impact of data from population-based studies is exemplified with analyses from the Swedish Acute Leukemia Registry containing over 3300 AML patients diagnosed 1997-2006 with a median follow-up of 6.2 years on (i) the role of intensive combination chemotherapy for older patients with AML, (ii) the impact of allogeneic stem cell transplantation on survival of younger patients with AML, and (iii) the continuing problem with early deaths in APL. We also present the first web-based dynamic graph showing the complex interaction between age, performance status, the proportion of patients given intensive treatment, early death rate, complete remission rate, use of allogeneic transplants and overall survival in AML (non-APL). (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
119
issue
17
pages
3890 - 3899
publisher
American Society of Hematology
external identifiers
  • wos:000305282900009
  • pmid:22383796
  • scopus:84860317991
ISSN
1528-0020
DOI
10.1182/blood-2011-12-379008
language
English
LU publication?
yes
id
0359dca7-58f7-400f-a0f6-53c281179bc4 (old id 2432327)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22383796?dopt=Abstract
date added to LUP
2012-04-03 08:15:32
date last changed
2017-11-12 04:06:44
@article{0359dca7-58f7-400f-a0f6-53c281179bc4,
  abstract     = {Population-based registries may provide data complementary to that from basic science and clinical intervention studies, all of which essential for establishing recommendations for the management of patients in the real world. The same quality criteria apply for the evidence-based label, and both high representation and good data quality are crucial in registry studies. Registries with high coverage of the target population reduce the impact of selection on outcome and the subsequent problem with extrapolating data to non-studied populations. Thus data, useful for clinical decision in situations not well covered by clinical studies, can be provided. The potential clinical impact of data from population-based studies is exemplified with analyses from the Swedish Acute Leukemia Registry containing over 3300 AML patients diagnosed 1997-2006 with a median follow-up of 6.2 years on (i) the role of intensive combination chemotherapy for older patients with AML, (ii) the impact of allogeneic stem cell transplantation on survival of younger patients with AML, and (iii) the continuing problem with early deaths in APL. We also present the first web-based dynamic graph showing the complex interaction between age, performance status, the proportion of patients given intensive treatment, early death rate, complete remission rate, use of allogeneic transplants and overall survival in AML (non-APL).},
  author       = {Juliusson, Gunnar and Lazarevic, Vladimir and Hörstedt, Ann-sofi and Hagberg, Oskar and Hoglund, Martin},
  issn         = {1528-0020},
  language     = {eng},
  number       = {17},
  pages        = {3890--3899},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {Acute myeloid leukemia in the real world: why population-based registries are needed.},
  url          = {http://dx.doi.org/10.1182/blood-2011-12-379008},
  volume       = {119},
  year         = {2012},
}