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Contrasting patterns of diversity and population differentiation at the innate immunity gene toll-like receptor 2 (tlr2) in two sympatric rodent species.

Tschirren, Barbara LU ; Andersson, Martin LU ; Scherman, Kristin LU ; Westerdahl, Helena LU and Råberg, Lars LU (2012) In Evolution 66(3). p.720-731
Abstract
Comparing patterns of diversity and divergence between populations at immune genes and neutral markers can give insights into the nature and geographic scale of parasite-mediated selection. To date, studies investigating such patterns of selection in vertebrates have primarily focused on the acquired branch of the immune system, whereas it remains largely unknown how parasite-mediated selection shapes innate immune genes both within and across vertebrate populations. Here, we present a study on the diversity and population differentiation at the innate immune gene Toll-like receptor 2 (TLR2) across nine populations of yellow-necked mice (Apodemus flavicollis) and bank voles (Myodes glareolus) in southern Sweden. In yellow-necked mice, TLR2... (More)
Comparing patterns of diversity and divergence between populations at immune genes and neutral markers can give insights into the nature and geographic scale of parasite-mediated selection. To date, studies investigating such patterns of selection in vertebrates have primarily focused on the acquired branch of the immune system, whereas it remains largely unknown how parasite-mediated selection shapes innate immune genes both within and across vertebrate populations. Here, we present a study on the diversity and population differentiation at the innate immune gene Toll-like receptor 2 (TLR2) across nine populations of yellow-necked mice (Apodemus flavicollis) and bank voles (Myodes glareolus) in southern Sweden. In yellow-necked mice, TLR2 diversity was very low, as was TLR2 population differentiation compared to neutral loci. In contrast, several TLR2 haplotypes co-occurred at intermediate frequencies within and across bank vole populations, and pronounced isolation by distance between populations was observed. The diversity and differentiation at neutral loci was similar in the two species. These results indicate that parasite-mediated selection has been acting in dramatically different ways on a given immune gene in ecologically similar and sympatric species. Furthermore, the finding of TLR2 population differentiation at a small geographical scale in bank voles highlights that vertebrate innate immune defense may be evolutionarily more dynamic than has previously been appreciated. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Evolution
volume
66
issue
3
pages
720 - 731
publisher
Wiley-Blackwell
external identifiers
  • wos:000300931400009
  • pmid:22380435
  • scopus:84857689959
ISSN
1558-5646
DOI
10.1111/j.1558-5646.2011.01473.x
project
Borrelia in rodents
CAnMove
language
English
LU publication?
yes
id
a8679b2d-3f9b-4c2d-9db2-351998dbba65 (old id 2432382)
date added to LUP
2012-05-08 10:38:40
date last changed
2017-01-22 03:56:42
@article{a8679b2d-3f9b-4c2d-9db2-351998dbba65,
  abstract     = {Comparing patterns of diversity and divergence between populations at immune genes and neutral markers can give insights into the nature and geographic scale of parasite-mediated selection. To date, studies investigating such patterns of selection in vertebrates have primarily focused on the acquired branch of the immune system, whereas it remains largely unknown how parasite-mediated selection shapes innate immune genes both within and across vertebrate populations. Here, we present a study on the diversity and population differentiation at the innate immune gene Toll-like receptor 2 (TLR2) across nine populations of yellow-necked mice (Apodemus flavicollis) and bank voles (Myodes glareolus) in southern Sweden. In yellow-necked mice, TLR2 diversity was very low, as was TLR2 population differentiation compared to neutral loci. In contrast, several TLR2 haplotypes co-occurred at intermediate frequencies within and across bank vole populations, and pronounced isolation by distance between populations was observed. The diversity and differentiation at neutral loci was similar in the two species. These results indicate that parasite-mediated selection has been acting in dramatically different ways on a given immune gene in ecologically similar and sympatric species. Furthermore, the finding of TLR2 population differentiation at a small geographical scale in bank voles highlights that vertebrate innate immune defense may be evolutionarily more dynamic than has previously been appreciated.},
  author       = {Tschirren, Barbara and Andersson, Martin and Scherman, Kristin and Westerdahl, Helena and Råberg, Lars},
  issn         = {1558-5646},
  language     = {eng},
  number       = {3},
  pages        = {720--731},
  publisher    = {Wiley-Blackwell},
  series       = {Evolution},
  title        = {Contrasting patterns of diversity and population differentiation at the innate immunity gene toll-like receptor 2 (tlr2) in two sympatric rodent species.},
  url          = {http://dx.doi.org/10.1111/j.1558-5646.2011.01473.x},
  volume       = {66},
  year         = {2012},
}