Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males
(2005) In Atherosclerosis 180(1). p.119-125- Abstract
- Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal... (More)
- Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal rate during the clamp (8.7 +/- 0.8 mg/kg LBM/min versus 10.3 +/- 1.3 mg/kg LBM/min; n.s.) did not differ significantly. Blood pressure, lipid parameters, adiponectin, endothelin-1 and CRP concentrations were similar. However, in the basal state, AIx was increased (129 +/- 4% versus 116 +/- 2%; p < 0.02) and Tr was decreased (150 +/- 3 ms versus 171 +/- 5 ms; P < 0.01), suggesting stiffer vessels in the LIRS-group. The LIRS-group exhibited an attenuated AIx response to hyperinsulinemia compared to the NIRS-group. Conclusions: The data suggest that non-obese non-diabetic men with a low adipocyte IRS-1 protein expression have an increased systemic arterial stiffness. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/243803
- author
- Sandqvist, M ; Nyberg, G ; Hammarstedt, A ; Klintland, N ; Gogg, S ; Caidahl, K ; Ahrén, Bo LU ; Smith, U and Jansson, PA
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- tissue, endothelium, insulin resistance, arterial stiffness, adipose, IRS-1
- in
- Atherosclerosis
- volume
- 180
- issue
- 1
- pages
- 119 - 125
- publisher
- Elsevier
- external identifiers
-
- wos:000228812700016
- pmid:15823284
- scopus:17044381272
- ISSN
- 1879-1484
- DOI
- 10.1016/j.atherosclerosis.2004.11.006
- language
- English
- LU publication?
- yes
- id
- 275b0661-6744-4eaf-af70-ab5e3bf28b85 (old id 243803)
- date added to LUP
- 2016-04-01 11:51:28
- date last changed
- 2024-01-07 23:08:11
@article{275b0661-6744-4eaf-af70-ab5e3bf28b85,
abstract = {{Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal rate during the clamp (8.7 +/- 0.8 mg/kg LBM/min versus 10.3 +/- 1.3 mg/kg LBM/min; n.s.) did not differ significantly. Blood pressure, lipid parameters, adiponectin, endothelin-1 and CRP concentrations were similar. However, in the basal state, AIx was increased (129 +/- 4% versus 116 +/- 2%; p < 0.02) and Tr was decreased (150 +/- 3 ms versus 171 +/- 5 ms; P < 0.01), suggesting stiffer vessels in the LIRS-group. The LIRS-group exhibited an attenuated AIx response to hyperinsulinemia compared to the NIRS-group. Conclusions: The data suggest that non-obese non-diabetic men with a low adipocyte IRS-1 protein expression have an increased systemic arterial stiffness.}},
author = {{Sandqvist, M and Nyberg, G and Hammarstedt, A and Klintland, N and Gogg, S and Caidahl, K and Ahrén, Bo and Smith, U and Jansson, PA}},
issn = {{1879-1484}},
keywords = {{tissue; endothelium; insulin resistance; arterial stiffness; adipose; IRS-1}},
language = {{eng}},
number = {{1}},
pages = {{119--125}},
publisher = {{Elsevier}},
series = {{Atherosclerosis}},
title = {{Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males}},
url = {{http://dx.doi.org/10.1016/j.atherosclerosis.2004.11.006}},
doi = {{10.1016/j.atherosclerosis.2004.11.006}},
volume = {{180}},
year = {{2005}},
}