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Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males

Sandqvist, M; Nyberg, G; Hammarstedt, A; Klintland, N; Gogg, S; Caidahl, K; Ahrén, Bo LU ; Smith, U and Jansson, PA (2005) In Atherosclerosis 180(1). p.119-125
Abstract
Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal... (More)
Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal rate during the clamp (8.7 +/- 0.8 mg/kg LBM/min versus 10.3 +/- 1.3 mg/kg LBM/min; n.s.) did not differ significantly. Blood pressure, lipid parameters, adiponectin, endothelin-1 and CRP concentrations were similar. However, in the basal state, AIx was increased (129 +/- 4% versus 116 +/- 2%; p < 0.02) and Tr was decreased (150 +/- 3 ms versus 171 +/- 5 ms; P < 0.01), suggesting stiffer vessels in the LIRS-group. The LIRS-group exhibited an attenuated AIx response to hyperinsulinemia compared to the NIRS-group. Conclusions: The data suggest that non-obese non-diabetic men with a low adipocyte IRS-1 protein expression have an increased systemic arterial stiffness. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tissue, endothelium, insulin resistance, arterial stiffness, adipose, IRS-1
in
Atherosclerosis
volume
180
issue
1
pages
119 - 125
publisher
Elsevier
external identifiers
  • wos:000228812700016
  • pmid:15823284
  • scopus:17044381272
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2004.11.006
language
English
LU publication?
yes
id
275b0661-6744-4eaf-af70-ab5e3bf28b85 (old id 243803)
date added to LUP
2007-08-16 16:06:16
date last changed
2017-01-01 04:36:33
@article{275b0661-6744-4eaf-af70-ab5e3bf28b85,
  abstract     = {Objective: Low adipocyte IRS-1 protein expression is a biomarker for insulin resistance and early atherosclerosis. However, whether IRS-1 protein expression is related to systemic arterial stiffness, is unknown. Methods and results: Ten non-diabetic male subjects with low adipocyte IRS-1 protein expression (NIRS) were matched with 10 non-diabetic males with normal IRS-1 protein expression (NIRS). Augmentation index (AIx) and time for reflection of pulse wave (Tr) were studied with pulse wave analysis, both in the fasting state and during a euglycemic hyperinsulinemic clamp. The LIRS-group showed an increased fasting insulin concentration (fP-insulin 71 +/- 4 pmol/L versus 58 +/- 5 pmol/L;p = 0.02 (mean +/- S.E.)), whereas glucose disposal rate during the clamp (8.7 +/- 0.8 mg/kg LBM/min versus 10.3 +/- 1.3 mg/kg LBM/min; n.s.) did not differ significantly. Blood pressure, lipid parameters, adiponectin, endothelin-1 and CRP concentrations were similar. However, in the basal state, AIx was increased (129 +/- 4% versus 116 +/- 2%; p &lt; 0.02) and Tr was decreased (150 +/- 3 ms versus 171 +/- 5 ms; P &lt; 0.01), suggesting stiffer vessels in the LIRS-group. The LIRS-group exhibited an attenuated AIx response to hyperinsulinemia compared to the NIRS-group. Conclusions: The data suggest that non-obese non-diabetic men with a low adipocyte IRS-1 protein expression have an increased systemic arterial stiffness.},
  author       = {Sandqvist, M and Nyberg, G and Hammarstedt, A and Klintland, N and Gogg, S and Caidahl, K and Ahrén, Bo and Smith, U and Jansson, PA},
  issn         = {1879-1484},
  keyword      = {tissue,endothelium,insulin resistance,arterial stiffness,adipose,IRS-1},
  language     = {eng},
  number       = {1},
  pages        = {119--125},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Low adipocyte IRS-1 protein expression is associated with an increased arterial stiffness in non-diabetic males},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2004.11.006},
  volume       = {180},
  year         = {2005},
}