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Characterisation of a cluster of TRIM-B30.2 genes in the chicken MHC B locus

Ruby, T; Bed'Hom, B; Wittzell, Håkan LU ; Morin, V; Oudin, A and Zoorob, R (2005) In Immunogenetics 57(1-2). p.116-128
Abstract
We have identified and characterised a cluster of six TRIM-B30.2 genes flanking the chicken BF/ BL region of the B complex. The TRIM-B30.2 proteins are a subgroup of the TRIM protein family containing the tripartite motif ( TRIM), consisting of a RING domain, a B-box and a coiled coil region, and a B30.2-like domain. In humans, a cluster of seven TRIM- B30.2 genes has been characterised within the MHC on Chromosome 6p21.33. Among the six chicken TRIM- B30.2 genes two are orthologous to those of the human MHC, and two (TRIM41 and TRIM7) are orthologous to human genes located on Chromosome 5. In humans, these last two genes are adjacent to GNB2L1, a guanine nucleotide-binding protein gene, the ortholog of the chicken c12.3 gene situated in... (More)
We have identified and characterised a cluster of six TRIM-B30.2 genes flanking the chicken BF/ BL region of the B complex. The TRIM-B30.2 proteins are a subgroup of the TRIM protein family containing the tripartite motif ( TRIM), consisting of a RING domain, a B-box and a coiled coil region, and a B30.2-like domain. In humans, a cluster of seven TRIM- B30.2 genes has been characterised within the MHC on Chromosome 6p21.33. Among the six chicken TRIM- B30.2 genes two are orthologous to those of the human MHC, and two (TRIM41 and TRIM7) are orthologous to human genes located on Chromosome 5. In humans, these last two genes are adjacent to GNB2L1, a guanine nucleotide-binding protein gene, the ortholog of the chicken c12.3 gene situated in the vicinity of the TRIM-B30.2 genes. This suggests that breakpoints specific to mammals have occurred and led to the remodelling of their MHC structure. In terms of structure, like their mammalian counterparts, each chicken gene consists of five coding exons; exon 1 encodes the RING domain and the B-box, exons 2, 3 and 4 form the coiled- coil region, and the last exon represents the B30.2- like domain. Phylogenetic analysis led us to assume that this extended BF/ BL region may be similar to the human extended class I region, because it contains cluster of BG genes sharing an Ig-V like domain with the BTN genes ( Henry et al. 1997a) and six TRIM-B30.2 genes containing the B30.2-like domain, shared with the TRIM-B30.2 members and the BTN genes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
B30.2 domain, TRIM, B locus
in
Immunogenetics
volume
57
issue
1-2
pages
116 - 128
publisher
Springer
external identifiers
  • wos:000228516000013
  • pmid:15744538
  • scopus:17844364254
ISSN
1432-1211
DOI
10.1007/s00251-005-0770-x
language
English
LU publication?
yes
id
6253a73b-fc38-4fb9-a674-5875ac937e6b (old id 245786)
date added to LUP
2007-08-07 17:30:28
date last changed
2017-01-08 04:56:16
@article{6253a73b-fc38-4fb9-a674-5875ac937e6b,
  abstract     = {We have identified and characterised a cluster of six TRIM-B30.2 genes flanking the chicken BF/ BL region of the B complex. The TRIM-B30.2 proteins are a subgroup of the TRIM protein family containing the tripartite motif ( TRIM), consisting of a RING domain, a B-box and a coiled coil region, and a B30.2-like domain. In humans, a cluster of seven TRIM- B30.2 genes has been characterised within the MHC on Chromosome 6p21.33. Among the six chicken TRIM- B30.2 genes two are orthologous to those of the human MHC, and two (TRIM41 and TRIM7) are orthologous to human genes located on Chromosome 5. In humans, these last two genes are adjacent to GNB2L1, a guanine nucleotide-binding protein gene, the ortholog of the chicken c12.3 gene situated in the vicinity of the TRIM-B30.2 genes. This suggests that breakpoints specific to mammals have occurred and led to the remodelling of their MHC structure. In terms of structure, like their mammalian counterparts, each chicken gene consists of five coding exons; exon 1 encodes the RING domain and the B-box, exons 2, 3 and 4 form the coiled- coil region, and the last exon represents the B30.2- like domain. Phylogenetic analysis led us to assume that this extended BF/ BL region may be similar to the human extended class I region, because it contains cluster of BG genes sharing an Ig-V like domain with the BTN genes ( Henry et al. 1997a) and six TRIM-B30.2 genes containing the B30.2-like domain, shared with the TRIM-B30.2 members and the BTN genes.},
  author       = {Ruby, T and Bed'Hom, B and Wittzell, Håkan and Morin, V and Oudin, A and Zoorob, R},
  issn         = {1432-1211},
  keyword      = {B30.2 domain,TRIM,B locus},
  language     = {eng},
  number       = {1-2},
  pages        = {116--128},
  publisher    = {Springer},
  series       = {Immunogenetics},
  title        = {Characterisation of a cluster of TRIM-B30.2 genes in the chicken MHC B locus},
  url          = {http://dx.doi.org/10.1007/s00251-005-0770-x},
  volume       = {57},
  year         = {2005},
}