In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light
(2005) In Applied Optics 44(11). p.2213-2220- Abstract
- A system based on a femtosecond white-light continuum and a streak camera was used for recordings of the in vivo absorption spectra of the tumor-seeking agent disulphonated aluminum phthalocyanine. Measurements for different drug doses were performed on tumor tissue (muscle-implanted adenocarcinoma) and normal muscle tissue in rats. It was found that the shape of the spectrum is tissue dependent. The peak of the absorption spectrum is blueshifted in tumor tissue as compared with the muscle. Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/245865
- author
- af Klinteberg, C ; Pifferi, A ; Andersson-Engels, Stefan LU ; Cubeddu, R and Svanberg, Sune LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Applied Optics
- volume
- 44
- issue
- 11
- pages
- 2213 - 2220
- publisher
- Optical Society of America
- external identifiers
-
- wos:000228457800021
- pmid:15835366
- scopus:18944375241
- ISSN
- 2155-3165
- language
- English
- LU publication?
- yes
- id
- d75d9824-7c08-469a-968e-992d2c437704 (old id 245865)
- alternative location
- http://ao.osa.org/DirectPDFAccess/6D74C266-BDB9-137E-CA635825A9BED746_83256.pdf?da=1&id=83256&seq=0&CFID=49892048&CFTOKEN=81354359
- date added to LUP
- 2016-04-01 11:42:43
- date last changed
- 2022-01-26 17:06:30
@article{d75d9824-7c08-469a-968e-992d2c437704, abstract = {{A system based on a femtosecond white-light continuum and a streak camera was used for recordings of the in vivo absorption spectra of the tumor-seeking agent disulphonated aluminum phthalocyanine. Measurements for different drug doses were performed on tumor tissue (muscle-implanted adenocarcinoma) and normal muscle tissue in rats. It was found that the shape of the spectrum is tissue dependent. The peak of the absorption spectrum is blueshifted in tumor tissue as compared with the muscle. Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength.}}, author = {{af Klinteberg, C and Pifferi, A and Andersson-Engels, Stefan and Cubeddu, R and Svanberg, Sune}}, issn = {{2155-3165}}, language = {{eng}}, number = {{11}}, pages = {{2213--2220}}, publisher = {{Optical Society of America}}, series = {{Applied Optics}}, title = {{In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light}}, url = {{https://lup.lub.lu.se/search/files/2606780/2370324.pdf}}, volume = {{44}}, year = {{2005}}, }