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In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light

af Klinteberg, C; Pifferi, A; Andersson-Engels, Stefan LU ; Cubeddu, R and Svanberg, Sune LU (2005) In Applied Optics 44(11). p.2213-2220
Abstract
A system based on a femtosecond white-light continuum and a streak camera was used for recordings of the in vivo absorption spectra of the tumor-seeking agent disulphonated aluminum phthalocyanine. Measurements for different drug doses were performed on tumor tissue (muscle-implanted adenocarcinoma) and normal muscle tissue in rats. It was found that the shape of the spectrum is tissue dependent. The peak of the absorption spectrum is blueshifted in tumor tissue as compared with the muscle. Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Optics
volume
44
issue
11
pages
2213 - 2220
publisher
OSA
external identifiers
  • wos:000228457800021
  • pmid:15835366
  • scopus:18944375241
ISSN
2155-3165
language
English
LU publication?
yes
id
d75d9824-7c08-469a-968e-992d2c437704 (old id 245865)
alternative location
http://ao.osa.org/DirectPDFAccess/6D74C266-BDB9-137E-CA635825A9BED746_83256.pdf?da=1&id=83256&seq=0&CFID=49892048&CFTOKEN=81354359
date added to LUP
2007-08-16 08:48:03
date last changed
2017-01-01 04:28:06
@article{d75d9824-7c08-469a-968e-992d2c437704,
  abstract     = {A system based on a femtosecond white-light continuum and a streak camera was used for recordings of the in vivo absorption spectra of the tumor-seeking agent disulphonated aluminum phthalocyanine. Measurements for different drug doses were performed on tumor tissue (muscle-implanted adenocarcinoma) and normal muscle tissue in rats. It was found that the shape of the spectrum is tissue dependent. The peak of the absorption spectrum is blueshifted in tumor tissue as compared with the muscle. Thus the contrast in the drug-related absorption can be altered by up to a factor of 2 from the primary drug molecular-concentration contrast between normal muscle and tumor by the proper selection of the illumination wavelength.},
  author       = {af Klinteberg, C and Pifferi, A and Andersson-Engels, Stefan and Cubeddu, R and Svanberg, Sune},
  issn         = {2155-3165},
  language     = {eng},
  number       = {11},
  pages        = {2213--2220},
  publisher    = {OSA},
  series       = {Applied Optics},
  title        = {In vivo absorption spectroscopy of tumor sensitizers with femtosecond white light},
  volume       = {44},
  year         = {2005},
}