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Human population studies with cytogenetic biomarkers: Review of the literature and future prospectives

Bonassi, S; Ugolini, D; Kirsch-Volders, M; Strömberg, Ulf LU ; Vermeulen, R and Tucker, JD (2005) In Environmental and Molecular Mutagenesis 45(2-3). p.258-270
Abstract
Cytogenetic biomarkers are by far the most frequently used endpoints in human population studies. Their sensitivity for measuring exposure to genotoxic agents and their role as early predictors of cancer risk have contributed to this success. In this article, we present an overview of the last 25 years of population studies with cytogenetic biomarkers, describing the evolution of this research and addressing the most promising innovations for the future. The evaluation has been restricted to the most popular assays, i.e., chromosomal aberrations (CAs) and micronucleus (MN), which are considered to be causally related to early stages of chronic diseases, especially cancer, and may therefore play a major role in prevention. An extensive... (More)
Cytogenetic biomarkers are by far the most frequently used endpoints in human population studies. Their sensitivity for measuring exposure to genotoxic agents and their role as early predictors of cancer risk have contributed to this success. In this article, we present an overview of the last 25 years of population studies with cytogenetic biomarkers, describing the evolution of this research and addressing the most promising innovations for the future. The evaluation has been restricted to the most popular assays, i.e., chromosomal aberrations (CAs) and micronucleus (MN), which are considered to be causally related to early stages of chronic diseases, especially cancer, and may therefore play a major role in prevention. An extensive literature search covering the period 1 January 1980 to 31 December 2003 was performed using the Medline/PubMed database. A total of 833 population studies using CAs and 434 using matched MN inclusion criteria were included in the analysis. We report the distribution of selected papers by year of publication, country, language, agents investigated, and methods employed. The state of the art and future prospects regarding cytogenetic techniques and epidemiologic and statistical methods are discussed. The role of susceptibility and its potential impact on genotoxic damage are discussed with special attention to the effect of major genetic polymorphisms on the baseline frequency of CAs and micronuclei. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
risk assessment, environmental exposure, review, molecular epidemiology, chromosomal aberrations, micronucleus test
in
Environmental and Molecular Mutagenesis
volume
45
issue
2-3
pages
258 - 270
publisher
John Wiley & Sons
external identifiers
  • wos:000228262500016
  • scopus:17044379064
ISSN
1098-2280
DOI
10.1002/em.20115
language
English
LU publication?
yes
id
445e892f-2a3d-4d11-8ce1-707e0ac79eb6 (old id 246519)
date added to LUP
2007-08-14 12:53:18
date last changed
2017-11-19 03:40:07
@article{445e892f-2a3d-4d11-8ce1-707e0ac79eb6,
  abstract     = {Cytogenetic biomarkers are by far the most frequently used endpoints in human population studies. Their sensitivity for measuring exposure to genotoxic agents and their role as early predictors of cancer risk have contributed to this success. In this article, we present an overview of the last 25 years of population studies with cytogenetic biomarkers, describing the evolution of this research and addressing the most promising innovations for the future. The evaluation has been restricted to the most popular assays, i.e., chromosomal aberrations (CAs) and micronucleus (MN), which are considered to be causally related to early stages of chronic diseases, especially cancer, and may therefore play a major role in prevention. An extensive literature search covering the period 1 January 1980 to 31 December 2003 was performed using the Medline/PubMed database. A total of 833 population studies using CAs and 434 using matched MN inclusion criteria were included in the analysis. We report the distribution of selected papers by year of publication, country, language, agents investigated, and methods employed. The state of the art and future prospects regarding cytogenetic techniques and epidemiologic and statistical methods are discussed. The role of susceptibility and its potential impact on genotoxic damage are discussed with special attention to the effect of major genetic polymorphisms on the baseline frequency of CAs and micronuclei.},
  author       = {Bonassi, S and Ugolini, D and Kirsch-Volders, M and Strömberg, Ulf and Vermeulen, R and Tucker, JD},
  issn         = {1098-2280},
  keyword      = {risk assessment,environmental exposure,review,molecular epidemiology,chromosomal aberrations,micronucleus test},
  language     = {eng},
  number       = {2-3},
  pages        = {258--270},
  publisher    = {John Wiley & Sons},
  series       = {Environmental and Molecular Mutagenesis},
  title        = {Human population studies with cytogenetic biomarkers: Review of the literature and future prospectives},
  url          = {http://dx.doi.org/10.1002/em.20115},
  volume       = {45},
  year         = {2005},
}