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Binding and activation of plasminogen at the surface of Fusobacterium necrophorum.

Holm, Karin LU and Rasmussen, Magnus LU (2013) In Microbial Pathogenesis 59-60(April,12). p.29-32
Abstract
Fusobacterium necrophorum is a gram-negative, anaerobic bacterium, which has been suggested to be a normal inhabitant of the oral flora. In rare cases, it can invade the tonsils and deeper tissues, causing the serious condition Lemièrre's syndrome. Recruitment of host plasminogen is a well-known bacterial virulence mechanism, and plasmin activity at the bacterial surface is thought to be important for bacterial invasion. Herein we show that plasminogen can be recruited to the surface of F. necrophorum, that surface-bound plasminogen is more easily converted to active plasmin than plasminogen in buffer, and that bound plasminogen is protected against inactivation by α2-antiplasmin. These findings add to the understanding of the pathogenesis... (More)
Fusobacterium necrophorum is a gram-negative, anaerobic bacterium, which has been suggested to be a normal inhabitant of the oral flora. In rare cases, it can invade the tonsils and deeper tissues, causing the serious condition Lemièrre's syndrome. Recruitment of host plasminogen is a well-known bacterial virulence mechanism, and plasmin activity at the bacterial surface is thought to be important for bacterial invasion. Herein we show that plasminogen can be recruited to the surface of F. necrophorum, that surface-bound plasminogen is more easily converted to active plasmin than plasminogen in buffer, and that bound plasminogen is protected against inactivation by α2-antiplasmin. These findings add to the understanding of the pathogenesis of Lemièrre's syndrome. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbial Pathogenesis
volume
59-60
issue
April,12
pages
29 - 32
publisher
Academic Press
external identifiers
  • wos:000319493100005
  • pmid:23583624
  • scopus:84877331808
ISSN
1096-1208
DOI
10.1016/j.micpath.2013.04.004
language
English
LU publication?
yes
id
248f61a2-9a1d-46b2-ac88-43aa59816f7e (old id 3733801)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23583624?dopt=Abstract
date added to LUP
2013-05-04 18:26:02
date last changed
2019-03-27 01:04:43
@article{248f61a2-9a1d-46b2-ac88-43aa59816f7e,
  abstract     = {Fusobacterium necrophorum is a gram-negative, anaerobic bacterium, which has been suggested to be a normal inhabitant of the oral flora. In rare cases, it can invade the tonsils and deeper tissues, causing the serious condition Lemièrre's syndrome. Recruitment of host plasminogen is a well-known bacterial virulence mechanism, and plasmin activity at the bacterial surface is thought to be important for bacterial invasion. Herein we show that plasminogen can be recruited to the surface of F. necrophorum, that surface-bound plasminogen is more easily converted to active plasmin than plasminogen in buffer, and that bound plasminogen is protected against inactivation by α2-antiplasmin. These findings add to the understanding of the pathogenesis of Lemièrre's syndrome.},
  author       = {Holm, Karin and Rasmussen, Magnus},
  issn         = {1096-1208},
  language     = {eng},
  number       = {April,12},
  pages        = {29--32},
  publisher    = {Academic Press},
  series       = {Microbial Pathogenesis},
  title        = {Binding and activation of plasminogen at the surface of Fusobacterium necrophorum.},
  url          = {http://dx.doi.org/10.1016/j.micpath.2013.04.004},
  volume       = {59-60},
  year         = {2013},
}