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The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer

Sun, Chen; Rosendahl, Ann LU ; Andersson, Roland LU ; Wu, DeQuan and Wang, Xiangdong (2011) In Pancreatology 11(2). p.252-260
Abstract
Background: Pancreatic cancer is a highly malignant cancer and the fourth leading cause of cancer-related death. It is characterized by a rapid disease progression, a highly invasive tumor phenotype, and frequently resistance to chemotherapy. Despite significant advances in diagnosis, staging, and surgical management of the disease during the past decade, prognosis of pancreatic cancer is still dismal. Methods and Results: The phosphatidylinositol 3-kinase (PI3K) signaling pathways regulate cellular growth, metabolism, survival, and motility in pancreatic cancer. Pancreatic cancer is associated with a high degree of genetic alterations that can result in aberrant activation of the PI3K signaling pathway. Elucidating the role of the PI3K... (More)
Background: Pancreatic cancer is a highly malignant cancer and the fourth leading cause of cancer-related death. It is characterized by a rapid disease progression, a highly invasive tumor phenotype, and frequently resistance to chemotherapy. Despite significant advances in diagnosis, staging, and surgical management of the disease during the past decade, prognosis of pancreatic cancer is still dismal. Methods and Results: The phosphatidylinositol 3-kinase (PI3K) signaling pathways regulate cellular growth, metabolism, survival, and motility in pancreatic cancer. Pancreatic cancer is associated with a high degree of genetic alterations that can result in aberrant activation of the PI3K signaling pathway. Elucidating the role of the PI3K signaling pathway in pancreatic cancer may thus be both meaningful and necessary. Conclusion: Improved knowledge of the PI3K signaling pathway in pancreatic cancer would furthermore be helpful in understanding mechanisms of tumor initiation and progression, and in identifying appropriate targeted anticancer treatment in pancreatic cancer. Copyright (C) 2011 S. Karger AG, Basel and IAP (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PI3K, Signaling pathway, Pancreatic cancer
in
Pancreatology
volume
11
issue
2
pages
252 - 260
publisher
Karger
external identifiers
  • wos:000298848400008
  • scopus:79957576837
ISSN
1424-3903
DOI
10.1159/000327715
language
English
LU publication?
yes
id
602d9c40-53cf-43b5-98d2-ac247a8a2d97 (old id 2494392)
date added to LUP
2012-05-08 07:53:15
date last changed
2017-01-01 03:04:01
@article{602d9c40-53cf-43b5-98d2-ac247a8a2d97,
  abstract     = {Background: Pancreatic cancer is a highly malignant cancer and the fourth leading cause of cancer-related death. It is characterized by a rapid disease progression, a highly invasive tumor phenotype, and frequently resistance to chemotherapy. Despite significant advances in diagnosis, staging, and surgical management of the disease during the past decade, prognosis of pancreatic cancer is still dismal. Methods and Results: The phosphatidylinositol 3-kinase (PI3K) signaling pathways regulate cellular growth, metabolism, survival, and motility in pancreatic cancer. Pancreatic cancer is associated with a high degree of genetic alterations that can result in aberrant activation of the PI3K signaling pathway. Elucidating the role of the PI3K signaling pathway in pancreatic cancer may thus be both meaningful and necessary. Conclusion: Improved knowledge of the PI3K signaling pathway in pancreatic cancer would furthermore be helpful in understanding mechanisms of tumor initiation and progression, and in identifying appropriate targeted anticancer treatment in pancreatic cancer. Copyright (C) 2011 S. Karger AG, Basel and IAP},
  author       = {Sun, Chen and Rosendahl, Ann and Andersson, Roland and Wu, DeQuan and Wang, Xiangdong},
  issn         = {1424-3903},
  keyword      = {PI3K,Signaling pathway,Pancreatic cancer},
  language     = {eng},
  number       = {2},
  pages        = {252--260},
  publisher    = {Karger},
  series       = {Pancreatology},
  title        = {The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer},
  url          = {http://dx.doi.org/10.1159/000327715},
  volume       = {11},
  year         = {2011},
}