Anticipation of age at onset in multiple sclerosis: methodologic pitfalls
(2010) In Acta Neurologica Scandinavica 121(6). p.426-428- Abstract
- Background/aim - There are several reports that claim anticipation in complex or polygenic diseases such as multiple sclerosis (MS), Crohn disease or schizophrenia. The aim of the present study was to assess age at onset of MS during the last 60 years in the region of Costa de Ponent (Barcelona, Spain) showing how apparent changes in age at onset between generations can be an artefact of analysis based on cohorts that have not been followed enough time. Methods - The study comprised 1100 patients diagnosed of MS. The method used to correct for follow-up time bias involves constructing comparison cohorts that had been observed for the same amount of time. To ensure equal follow-up times, we restricted our analysis to patients whose onset... (More)
- Background/aim - There are several reports that claim anticipation in complex or polygenic diseases such as multiple sclerosis (MS), Crohn disease or schizophrenia. The aim of the present study was to assess age at onset of MS during the last 60 years in the region of Costa de Ponent (Barcelona, Spain) showing how apparent changes in age at onset between generations can be an artefact of analysis based on cohorts that have not been followed enough time. Methods - The study comprised 1100 patients diagnosed of MS. The method used to correct for follow-up time bias involves constructing comparison cohorts that had been observed for the same amount of time. To ensure equal follow-up times, we restricted our analysis to patients whose onset was by 37 years of age (percentile 75) and were at least 37 years old. We analysed differences in age at onset using log-rank test to compare survival curves estimated by Kaplan-Meier method. Results - Age at onset decreases progressively from older to younger generations. However, when adjustment to equal follow-up time was done, anticipation in age at onset was not found. Conclusion - Anticipation of age at onset is undetectable when adjusted for follow-up time. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1617639
- author
- Alonso Magdalena, Lucia LU ; Romero-Pinel, L. ; Moral, E. ; Carmona, O. ; Gubieras, L. ; Ramon, J. M. ; Martinez-Yelamos, S. and Arbizu, T.
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- natural history, multiple sclerosis, epidemiology, demyelinating diseases, age at onset, anticipation
- in
- Acta Neurologica Scandinavica
- volume
- 121
- issue
- 6
- pages
- 426 - 428
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000277783900011
- scopus:77952594650
- pmid:20578997
- ISSN
- 1600-0404
- DOI
- 10.1111/j.1600-0404.2009.01273.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Malmö (013027010)
- id
- 24ddfa63-56ae-4148-b1cb-88be158e1e7d (old id 1617639)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20578997?dopt=Abstract
- date added to LUP
- 2016-04-01 13:52:18
- date last changed
- 2022-01-27 21:32:48
@misc{24ddfa63-56ae-4148-b1cb-88be158e1e7d, abstract = {{Background/aim - There are several reports that claim anticipation in complex or polygenic diseases such as multiple sclerosis (MS), Crohn disease or schizophrenia. The aim of the present study was to assess age at onset of MS during the last 60 years in the region of Costa de Ponent (Barcelona, Spain) showing how apparent changes in age at onset between generations can be an artefact of analysis based on cohorts that have not been followed enough time. Methods - The study comprised 1100 patients diagnosed of MS. The method used to correct for follow-up time bias involves constructing comparison cohorts that had been observed for the same amount of time. To ensure equal follow-up times, we restricted our analysis to patients whose onset was by 37 years of age (percentile 75) and were at least 37 years old. We analysed differences in age at onset using log-rank test to compare survival curves estimated by Kaplan-Meier method. Results - Age at onset decreases progressively from older to younger generations. However, when adjustment to equal follow-up time was done, anticipation in age at onset was not found. Conclusion - Anticipation of age at onset is undetectable when adjusted for follow-up time.}}, author = {{Alonso Magdalena, Lucia and Romero-Pinel, L. and Moral, E. and Carmona, O. and Gubieras, L. and Ramon, J. M. and Martinez-Yelamos, S. and Arbizu, T.}}, issn = {{1600-0404}}, keywords = {{natural history; multiple sclerosis; epidemiology; demyelinating diseases; age at onset; anticipation}}, language = {{eng}}, number = {{6}}, pages = {{426--428}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Neurologica Scandinavica}}, title = {{Anticipation of age at onset in multiple sclerosis: methodologic pitfalls}}, url = {{http://dx.doi.org/10.1111/j.1600-0404.2009.01273.x}}, doi = {{10.1111/j.1600-0404.2009.01273.x}}, volume = {{121}}, year = {{2010}}, }