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Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker diabetic fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV

Gram, DX; Hansen, AJ; Deacon, CF; Brand, CL; Ribel, U; Wilken, M; Carr, RD; Svendsen, O and Ahrén, Bo LU (2005) In European Journal of Pharmacology 509(2-3). p.211-217
Abstract
Sensory nerve desensitization by capsaicin has been shown to improve the diabetic condition in Zucker Diabetic Fatty rats. However, administration of capsaicin to adult rats is associated with an increased mortality. Therefore, in this experiment, we examined the influence of resiniferatoxin, a tolerable analogue of capsaicin suitable for in vivo use, on the diabetic condition of Zucker Diabetic Fatty rats. A single subcutaneous injection of resiniferatoxin (0.01 mg/kg) to these rats was tolerable, with no mortality. When administered to early diabetic rats at 15 weeks of age, the further deterioration of glucose homeostasis was prevented by resiniferatoxin. Further, when administered to overtly diabetic rats at 19 weeks of age,... (More)
Sensory nerve desensitization by capsaicin has been shown to improve the diabetic condition in Zucker Diabetic Fatty rats. However, administration of capsaicin to adult rats is associated with an increased mortality. Therefore, in this experiment, we examined the influence of resiniferatoxin, a tolerable analogue of capsaicin suitable for in vivo use, on the diabetic condition of Zucker Diabetic Fatty rats. A single subcutaneous injection of resiniferatoxin (0.01 mg/kg) to these rats was tolerable, with no mortality. When administered to early diabetic rats at 15 weeks of age, the further deterioration of glucose homeostasis was prevented by resiniferatoxin. Further, when administered to overtly diabetic rats at 19 weeks of age, resiniferatoxin markedly improved glucose tolerance at two weeks after administration and this was accompanied by an increased insulin response to oral glucose as well as a reduction in the plasma levels of dipeptidyl peptidase IV. Therefore, resiniferatoxin is a safe alternative to capsaicin for further investigations of the role of the sensory nerves in experimental diabetes. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
dipeptidyl peptidase IV, sensory nerve, resiniferatoxin, diabetes, (Zucker diabetic fatty rat)
in
European Journal of Pharmacology
volume
509
issue
2-3
pages
211 - 217
publisher
Elsevier
external identifiers
  • wos:000227466100016
  • pmid:15733558
  • scopus:14044260472
ISSN
1879-0712
DOI
10.1016/j.ejphar.2004.12.039
language
English
LU publication?
yes
id
19dd9de1-b7d3-4a0b-8548-e31656370c5c (old id 250009)
date added to LUP
2007-08-24 13:26:00
date last changed
2017-09-10 03:46:52
@article{19dd9de1-b7d3-4a0b-8548-e31656370c5c,
  abstract     = {Sensory nerve desensitization by capsaicin has been shown to improve the diabetic condition in Zucker Diabetic Fatty rats. However, administration of capsaicin to adult rats is associated with an increased mortality. Therefore, in this experiment, we examined the influence of resiniferatoxin, a tolerable analogue of capsaicin suitable for in vivo use, on the diabetic condition of Zucker Diabetic Fatty rats. A single subcutaneous injection of resiniferatoxin (0.01 mg/kg) to these rats was tolerable, with no mortality. When administered to early diabetic rats at 15 weeks of age, the further deterioration of glucose homeostasis was prevented by resiniferatoxin. Further, when administered to overtly diabetic rats at 19 weeks of age, resiniferatoxin markedly improved glucose tolerance at two weeks after administration and this was accompanied by an increased insulin response to oral glucose as well as a reduction in the plasma levels of dipeptidyl peptidase IV. Therefore, resiniferatoxin is a safe alternative to capsaicin for further investigations of the role of the sensory nerves in experimental diabetes.},
  author       = {Gram, DX and Hansen, AJ and Deacon, CF and Brand, CL and Ribel, U and Wilken, M and Carr, RD and Svendsen, O and Ahrén, Bo},
  issn         = {1879-0712},
  keyword      = {dipeptidyl peptidase IV,sensory nerve,resiniferatoxin,diabetes,(Zucker diabetic fatty rat)},
  language     = {eng},
  number       = {2-3},
  pages        = {211--217},
  publisher    = {Elsevier},
  series       = {European Journal of Pharmacology},
  title        = {Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker diabetic fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV},
  url          = {http://dx.doi.org/10.1016/j.ejphar.2004.12.039},
  volume       = {509},
  year         = {2005},
}