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Carrier medium exchange through ultrasonic particle switching in microfluidic channels

Petersson, Filip LU ; Lenshof, Andreas LU ; Bjursten, Henrik LU and Laurell, Thomas LU (2005) In Analytical Chemistry 77(5). p.1216-1221
Abstract
This paper describes a method, utilizing acoustic force manipulation of suspended particles, in which particles in a laminar flow microchannel are continuously translated from one medium to another with virtually no mixing of the two media. During the study, 5-mum polyamide spheres suspended in distilled water, spiked (contaminated) with Evans blue, were switched over to clean distilled water. More than 95% of the polyamide spheres could be collected in the clean medium while removing up to 95% of the contaminant. Preliminary experiments to use this method to wash blood were performed. Red blood cells were switched from blood, spiked with Evans blue, to clean blood plasma. At least 95% of the red blood cells (bovine blood) could be... (More)
This paper describes a method, utilizing acoustic force manipulation of suspended particles, in which particles in a laminar flow microchannel are continuously translated from one medium to another with virtually no mixing of the two media. During the study, 5-mum polyamide spheres suspended in distilled water, spiked (contaminated) with Evans blue, were switched over to clean distilled water. More than 95% of the polyamide spheres could be collected in the clean medium while removing up to 95% of the contaminant. Preliminary experiments to use this method to wash blood were performed. Red blood cells were switched from blood, spiked with Evans blue, to clean blood plasma. At least 95% of the red blood cells (bovine blood) could be collected in clean blood plasma while up to 98% of the contaminant was removed. The obtained results indicate that the presented method can be used as a generic method for particle washing and, more specifically, be applied for both intraoperative and postoperative blood washing. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Chemistry
volume
77
issue
5
pages
1216 - 1221
publisher
The American Chemical Society
external identifiers
  • wos:000227409800010
  • scopus:14744269752
ISSN
1520-6882
DOI
10.1021/ac048394q
language
English
LU publication?
yes
id
c95240fc-a82f-4823-b06f-3c18cfba092f (old id 250996)
date added to LUP
2007-08-07 17:16:06
date last changed
2017-09-24 03:45:38
@article{c95240fc-a82f-4823-b06f-3c18cfba092f,
  abstract     = {This paper describes a method, utilizing acoustic force manipulation of suspended particles, in which particles in a laminar flow microchannel are continuously translated from one medium to another with virtually no mixing of the two media. During the study, 5-mum polyamide spheres suspended in distilled water, spiked (contaminated) with Evans blue, were switched over to clean distilled water. More than 95% of the polyamide spheres could be collected in the clean medium while removing up to 95% of the contaminant. Preliminary experiments to use this method to wash blood were performed. Red blood cells were switched from blood, spiked with Evans blue, to clean blood plasma. At least 95% of the red blood cells (bovine blood) could be collected in clean blood plasma while up to 98% of the contaminant was removed. The obtained results indicate that the presented method can be used as a generic method for particle washing and, more specifically, be applied for both intraoperative and postoperative blood washing.},
  author       = {Petersson, Filip and Lenshof, Andreas and Bjursten, Henrik and Laurell, Thomas},
  issn         = {1520-6882},
  language     = {eng},
  number       = {5},
  pages        = {1216--1221},
  publisher    = {The American Chemical Society},
  series       = {Analytical Chemistry},
  title        = {Carrier medium exchange through ultrasonic particle switching in microfluidic channels},
  url          = {http://dx.doi.org/10.1021/ac048394q},
  volume       = {77},
  year         = {2005},
}