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A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia

Arnheim, L; Dillner, Joakim LU and Sanjeevi, CB (2005) In Tissue Antigens 65(3). p.252-259
Abstract
Natural killer (NK) cells are involved both in control of virus infections and in elimination of tumor cells. Killer immunoglobulin-like receptors (KIRs) either activate or inhibit NK cell-mediated cytolysis, protecting healthy cells from destruction while enabling killing of abnormal cells. To investigate whether KIR genes or genotypes are associated with cervical carcinogenesis, a nested case-control study of 65 case women with cervical intraepithelial neoplasia (CIN) diagnosed during a 6-year follow-up of 15,234 women and 150 control women from the same cohort that remained healthy was performed. More than 70 different genotypes were observed, and 33 of which had not been described previously. An A-genotype including KIR2DL1, KIR2DL2,... (More)
Natural killer (NK) cells are involved both in control of virus infections and in elimination of tumor cells. Killer immunoglobulin-like receptors (KIRs) either activate or inhibit NK cell-mediated cytolysis, protecting healthy cells from destruction while enabling killing of abnormal cells. To investigate whether KIR genes or genotypes are associated with cervical carcinogenesis, a nested case-control study of 65 case women with cervical intraepithelial neoplasia (CIN) diagnosed during a 6-year follow-up of 15,234 women and 150 control women from the same cohort that remained healthy was performed. More than 70 different genotypes were observed, and 33 of which had not been described previously. An A-genotype including KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR3DL1, KIR3DL2, KIR3DL3, and KIR2DS4 was associated with increased risk of CIN (OR 6.7; 95% CI 1.7-26.3), and KIR2DL5B*002 appeared to have an inverse association with disease (OR 0.5; 95% CI 0.5-2.9). There was no association of CIN with the number of activating KIR genes. There was also no association between KIR genes and type of human papilloma virus or with other CIN-related immune response genes. It was concluded that certain KIR genes and genotypes may associate with cervical neoplasia. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
HPV, CIN, genotype, KIR
in
Tissue Antigens
volume
65
issue
3
pages
252 - 259
publisher
Wiley-Blackwell
external identifiers
  • pmid:15730517
  • wos:000227188800004
  • scopus:14844310289
ISSN
0001-2815
DOI
10.1111/j.1399-0039.2005.00359.x
language
English
LU publication?
yes
id
bc79827e-7230-4ff1-b3f3-c52b4ab7e281 (old id 251032)
date added to LUP
2007-08-02 11:29:37
date last changed
2017-11-15 14:17:21
@article{bc79827e-7230-4ff1-b3f3-c52b4ab7e281,
  abstract     = {Natural killer (NK) cells are involved both in control of virus infections and in elimination of tumor cells. Killer immunoglobulin-like receptors (KIRs) either activate or inhibit NK cell-mediated cytolysis, protecting healthy cells from destruction while enabling killing of abnormal cells. To investigate whether KIR genes or genotypes are associated with cervical carcinogenesis, a nested case-control study of 65 case women with cervical intraepithelial neoplasia (CIN) diagnosed during a 6-year follow-up of 15,234 women and 150 control women from the same cohort that remained healthy was performed. More than 70 different genotypes were observed, and 33 of which had not been described previously. An A-genotype including KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR3DL1, KIR3DL2, KIR3DL3, and KIR2DS4 was associated with increased risk of CIN (OR 6.7; 95% CI 1.7-26.3), and KIR2DL5B*002 appeared to have an inverse association with disease (OR 0.5; 95% CI 0.5-2.9). There was no association of CIN with the number of activating KIR genes. There was also no association between KIR genes and type of human papilloma virus or with other CIN-related immune response genes. It was concluded that certain KIR genes and genotypes may associate with cervical neoplasia.},
  author       = {Arnheim, L and Dillner, Joakim and Sanjeevi, CB},
  issn         = {0001-2815},
  keyword      = {HPV,CIN,genotype,KIR},
  language     = {eng},
  number       = {3},
  pages        = {252--259},
  publisher    = {Wiley-Blackwell},
  series       = {Tissue Antigens},
  title        = {A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia},
  url          = {http://dx.doi.org/10.1111/j.1399-0039.2005.00359.x},
  volume       = {65},
  year         = {2005},
}