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Formation of Bone-like Nanocrystalline Apatite Using Self-Assembled Liquid Crystals

He, Wenxiao; Kjellin, Per; Currie, Fredrik; Handa, Paul; Knee, Christopher S.; Bielecki, Johan; Wallenberg, Reine LU and Andersson, Martin (2012) In Chemistry of Materials 24(5). p.892-902
Abstract
A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were... (More)
A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were characterized by X-ray diffraction, conventional and high-resolution transmission electron microscopy, nitrogen adsorption, thermogravimetry with infrared-coupled analysis, and Raman spectroscopy. The PCA formed using the LC aging route presented bone-resembling features, such as,Ca2+ and OH- deficiency, CO32- substitution, poor crystallinity; and ultrahigh SSA of 356 m(2)/g. The resulting particles were compared to hydroxyapatite synthesized via a conventional water-based precipitation method. The LC-aging route exhibited excellent controllability over the CaP crystallization, which enabled facile tailoring of the resulting material properties for different types of application. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
liquid crystalline phase, nanoparticles, calcium, phosphate, apatite, bone
in
Chemistry of Materials
volume
24
issue
5
pages
892 - 902
publisher
The American Chemical Society
external identifiers
  • wos:000301398100015
  • scopus:84858233138
ISSN
0897-4756
DOI
10.1021/cm201077t
language
English
LU publication?
yes
id
873ec1ca-f7c6-4c75-8b21-1a6f3f571d2d (old id 2515532)
date added to LUP
2012-05-09 14:25:50
date last changed
2017-08-13 03:11:59
@article{873ec1ca-f7c6-4c75-8b21-1a6f3f571d2d,
  abstract     = {A two-step process using liquid crystalline phases combined with controlled postcrystallization for the preparation of bone-like apatite has been developed. First, amorphous calcium phosphate (ACP) spherules with a diameter of 10.8 +/- 1.4 nm and specific surface area (SSA) in the range of 150-170 m(2)/g were synthesized within a reverse hexagonal liquid crystalline (LC) phase. Second, the ACP spherules were dispersed and aged in Milli-Qwater, where they crystallized into poorly crystalline apatite (PCA). The addition of heparin during aging was explored, which was shown to retard the ACP - PCA conversion. The particle formation within the LC phase was monitored using synchrotron small-angle X-ray scattering, and the formed materials were characterized by X-ray diffraction, conventional and high-resolution transmission electron microscopy, nitrogen adsorption, thermogravimetry with infrared-coupled analysis, and Raman spectroscopy. The PCA formed using the LC aging route presented bone-resembling features, such as,Ca2+ and OH- deficiency, CO32- substitution, poor crystallinity; and ultrahigh SSA of 356 m(2)/g. The resulting particles were compared to hydroxyapatite synthesized via a conventional water-based precipitation method. The LC-aging route exhibited excellent controllability over the CaP crystallization, which enabled facile tailoring of the resulting material properties for different types of application.},
  author       = {He, Wenxiao and Kjellin, Per and Currie, Fredrik and Handa, Paul and Knee, Christopher S. and Bielecki, Johan and Wallenberg, Reine and Andersson, Martin},
  issn         = {0897-4756},
  keyword      = {liquid crystalline phase,nanoparticles,calcium,phosphate,apatite,bone},
  language     = {eng},
  number       = {5},
  pages        = {892--902},
  publisher    = {The American Chemical Society},
  series       = {Chemistry of Materials},
  title        = {Formation of Bone-like Nanocrystalline Apatite Using Self-Assembled Liquid Crystals},
  url          = {http://dx.doi.org/10.1021/cm201077t},
  volume       = {24},
  year         = {2012},
}