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Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study

Gram, Inger T.; Lukanova, Annekatrin; Brill, Ilene; Braaten, Tonje; Lund, Eiliv; Lundin, Eva; Overvad, Kim; Tjonneland, Anne; Clavel-Chapelon, Francoise and Chabbert-Buffet, Nathalie, et al. (2012) In International Journal of Cancer 130(9). p.2204-2210
Abstract
New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall... (More)
New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95% CI 1.083.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95% CI 1.264.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI 1.074.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype. (Less)
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publication status
published
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keywords
EPIC cohort, serous, mucinous, smoking, ovarian cancer
in
International Journal of Cancer
volume
130
issue
9
pages
2204 - 2210
publisher
John Wiley & Sons
external identifiers
  • wos:000300693100026
  • scopus:84857502264
ISSN
0020-7136
DOI
10.1002/ijc.26235
language
English
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yes
id
309506e2-bef1-4688-884b-784078da785c (old id 2516948)
date added to LUP
2012-05-07 08:02:04
date last changed
2017-07-30 03:24:17
@article{309506e2-bef1-4688-884b-784078da785c,
  abstract     = {New data regarding a positive association between smoking and risk of epithelial ovarian cancer (EOC), especially the mucinous tumor type, has started to emerge. The purpose of this study was to examine the association between different measures of smoking exposures and subtypes of EOC in a large cohort of women from 10 European countries. The European Prospective Investigation into Cancer and Nutrition (EPIC) cohort is a multicenter prospective study initiated in 1992. The questionnaires included data about dietary, lifestyle, and health factors. Information about cigarette smoking was collected from individuals in all participating countries. We used Cox proportional hazard regression models to estimate hazard ratio (HR) of EOC overall and serous, mucinous, and endometroid histological subtypes, with 95% confidence intervals (CIs) associated with different measures of smoking exposures adjusting for confounding variables. Altogether 836 incident EOC cases were identified among 326,831 women. The tumors were classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell, and 238 unspecified. Compared with never smokers, current smokers had a significantly increased risk for mucinous tumors [HR = 1.85 (95% CI 1.083.16)] and those smoking more than 10 cigarettes per day had a doubling in risk [HR = 2.25(95% CI 1.264.03)] as did those who had smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI 1.074.43)]. The results from the EPIC study add further evidence that smoking increases risk of mucinous ovarian cancer and support the notion that the effect of smoking varies according to histological subtype.},
  author       = {Gram, Inger T. and Lukanova, Annekatrin and Brill, Ilene and Braaten, Tonje and Lund, Eiliv and Lundin, Eva and Overvad, Kim and Tjonneland, Anne and Clavel-Chapelon, Francoise and Chabbert-Buffet, Nathalie and Bamia, Christina and Trichopoulou, Antonia and Zylis, Dimosthenis and Masala, Giovanna and Berrino, Franco and Galasso, Rocco and Tumino, Rosario and Sacerdote, Carlotta and Gavrilyuk, Oxana and Kristiansen, Steinar and Rodriguez, Laudina and Bonet, Catalina and Maria Huerta, Jose and Barricarte, Aurelio and Sanchez, Maria-Jose and Dorronsoro, Miren and Jirström, Karin and Almquist, Martin and Idahl, Annika and Bueno-de-Mesquita, H. Bas and Braem, Marie and Onland-Moret, Charlotte and Tsilidis, Konstantinos K. and Allen, Naomi E. and Fedirko, Veronika and Riboli, E. and Kaaks, Rudolf},
  issn         = {0020-7136},
  keyword      = {EPIC cohort,serous,mucinous,smoking,ovarian cancer},
  language     = {eng},
  number       = {9},
  pages        = {2204--2210},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Cigarette smoking and risk of histological subtypes of epithelial ovarian cancer in the EPIC cohort study},
  url          = {http://dx.doi.org/10.1002/ijc.26235},
  volume       = {130},
  year         = {2012},
}