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Nitrosamines and Heme Iron and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition

Jakszyn, Paula G.; Allen, Naomi E.; Lujan-Barroso, Leila; Gonzalez, Carlos A.; Key, Timothy J.; Fonseca-Nunes, Ana; Tjonneland, Anne; Fons-Johnsen, Nina; Overvad, Kim and Teucher, Birgit, et al. (2012) In Cancer Epidemiology Biomarkers & Prevention 21(3). p.547-551
Abstract
Background: The evidence about nitrosamines and heme iron intake and cancer risk is limited, despite the biologic plausibility of the hypothesis that these factors might increase cancer risk. We investigated the association between dietary nitrosamines and heme iron and the risk of prostate cancer among participants of European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence was available for 139,005 men, recruited in 8 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, and study center, and adjusted for total energy intake, smoking status, marital status, dairy products, educational... (More)
Background: The evidence about nitrosamines and heme iron intake and cancer risk is limited, despite the biologic plausibility of the hypothesis that these factors might increase cancer risk. We investigated the association between dietary nitrosamines and heme iron and the risk of prostate cancer among participants of European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence was available for 139,005 men, recruited in 8 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, and study center, and adjusted for total energy intake, smoking status, marital status, dairy products, educational level, and body mass index. Results: After a mean follow-up of 10 years, 4,606 participants were diagnosed with first incident prostate cancer. There was no overall association between prostate cancer risk and nitrosamines exposure (preformed and endogenous) or heme iron intake (HR for a doubling of intake: 1.00; 95% CI: 0.98-1.03 for N-Nitrosodimethlyamine, 0.95; 95% CI: 0.88-1.03 for endogenous Nitrosocompounds, and 1.00; 95 CI: 0.97-1.03 for heme iron). Conclusions and Impact: Our findings do not support an effect of nitrosamines (endogenous and exogenous) and heme iron intake on prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 21(3); 547-51. (C) 2012 AACR. (Less)
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Cancer Epidemiology Biomarkers & Prevention
volume
21
issue
3
pages
547 - 551
publisher
American Association for Cancer Research
external identifiers
  • wos:000301284100020
  • scopus:84859404206
ISSN
1538-7755
DOI
10.1158/1055-9965.EPI-11-1181
language
English
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yes
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39783290-1869-40df-9981-4549f09a6fb9 (old id 2517231)
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2012-05-07 07:52:56
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2017-10-01 04:03:08
@article{39783290-1869-40df-9981-4549f09a6fb9,
  abstract     = {Background: The evidence about nitrosamines and heme iron intake and cancer risk is limited, despite the biologic plausibility of the hypothesis that these factors might increase cancer risk. We investigated the association between dietary nitrosamines and heme iron and the risk of prostate cancer among participants of European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Data on food consumption and complete follow-up for cancer occurrence was available for 139,005 men, recruited in 8 European countries. Estimates of HRs were obtained by proportional hazard models, stratified by age at recruitment, and study center, and adjusted for total energy intake, smoking status, marital status, dairy products, educational level, and body mass index. Results: After a mean follow-up of 10 years, 4,606 participants were diagnosed with first incident prostate cancer. There was no overall association between prostate cancer risk and nitrosamines exposure (preformed and endogenous) or heme iron intake (HR for a doubling of intake: 1.00; 95% CI: 0.98-1.03 for N-Nitrosodimethlyamine, 0.95; 95% CI: 0.88-1.03 for endogenous Nitrosocompounds, and 1.00; 95 CI: 0.97-1.03 for heme iron). Conclusions and Impact: Our findings do not support an effect of nitrosamines (endogenous and exogenous) and heme iron intake on prostate cancer risk. Cancer Epidemiol Biomarkers Prev; 21(3); 547-51. (C) 2012 AACR.},
  author       = {Jakszyn, Paula G. and Allen, Naomi E. and Lujan-Barroso, Leila and Gonzalez, Carlos A. and Key, Timothy J. and Fonseca-Nunes, Ana and Tjonneland, Anne and Fons-Johnsen, Nina and Overvad, Kim and Teucher, Birgit and Li, Kuanrong and Boeing, Heiner and Trichopoulou, Antonia and Oikonomou, Eleni and Sarantopoulou, Maria and Saieva, Calogero and Krogh, Vittorio and Tumino, Rosario and Ricceri, Fulvio and Bueno-de-Mesquita, H. Bas and Huerta, Jose M. and Ardanaz, Eva and Arguelles, Marcial V. and Molina-Montes, Esther and Larranaga, Nerea and Wirfält, Elisabet and Wallström, Peter and Johansson, Mattias and Stattin, Paer and Khaw, Kay-Tee and Jenab, Mazda and Fedirko, Veronika and Riboli, Elio},
  issn         = {1538-7755},
  language     = {eng},
  number       = {3},
  pages        = {547--551},
  publisher    = {American Association for Cancer Research},
  series       = {Cancer Epidemiology Biomarkers & Prevention},
  title        = {Nitrosamines and Heme Iron and Risk of Prostate Cancer in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1158/1055-9965.EPI-11-1181},
  volume       = {21},
  year         = {2012},
}