Early single-channel aEEG/EEG predicts outcome in very preterm infants.
Wikström, Sverre ; Pupp, Ingrid LU
; Rosén, Ingmar
LU
; Norman, Elisabeth
LU
; Fellman, Vineta
LU
; Ley, David
LU
and Hellström-Westas, Lena
LU
(2012)
In Acta paediatrica
101(7).
p.719-726
- Abstract
- Aim: To characterize early amplitude-integrated electroencephalogram (aEEG) and single-channel EEG (aEEG/EEG) in very preterm (VPT) infants for prediction of long-term outcome. Patients: Forty-nine infants with median (range) gestational age of 25 (22-30) weeks.
Methods: Amplitude-integrated electroencephalogram/EEG recorded during the first 72 h and analysed over 0-12, 12-24, 24-48 and 48-72 h, for background pattern, sleep-wake cycling, seizures, interburst intervals (IBI) and interburst percentage (IB%). In total, 2614 h of single-channel EEG examined for seizures. Survivors were assessed at 2 years corrected age with a neurological examination and Bayley Scales of Infant Development-II. Poor outcome was defined as... (More) - Aim: To characterize early amplitude-integrated electroencephalogram (aEEG) and single-channel EEG (aEEG/EEG) in very preterm (VPT) infants for prediction of long-term outcome. Patients: Forty-nine infants with median (range) gestational age of 25 (22-30) weeks.
Methods: Amplitude-integrated electroencephalogram/EEG recorded during the first 72 h and analysed over 0-12, 12-24, 24-48 and 48-72 h, for background pattern, sleep-wake cycling, seizures, interburst intervals (IBI) and interburst percentage (IB%). In total, 2614 h of single-channel EEG examined for seizures. Survivors were assessed at 2 years corrected age with a neurological examination and Bayley Scales of Infant Development-II. Poor outcome was defined as death or survival with neurodevelopmental impairment. Good outcome was defined as survival without impairment.
Results: Thirty infants had good outcome. Poor outcome (n = 19) was associated with depressed aEEG/EEG already during the first 12 h (p = 0.023), and with prolonged IBI and higher IB% at 24 h. Seizures were present in 43% of the infants and associated with intraventricular haemorrhages but not with outcome. Best predictors of poor outcome were burst-suppression pattern [76% correctly predicted; positive predictive value (PPV) 63%, negative predictive value (NPV) 91%], IBI > 6 sec (74% correctly predicted; PPV 67%, NPV 79%) and IB% > 55% at 24 h age (79% correctly predicted; PPV 72%, NPV 80%). In 35 infants with normal cerebral ultrasound during the first 3 days, outcome was correctly predicted in 82% by IB% (PPV 82%, NPV 83%).
Conclusion: Long-term outcome can be predicted by aEEG/EEG with 75-80% accuracy already at 24 postnatal hours in VPT infants, also in infants with no early indication of brain injury. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2519078
- author
- Wikström, Sverre
; Pupp, Ingrid
LU
; Rosén, Ingmar
LU
; Norman, Elisabeth
LU
; Fellman, Vineta
LU
; Ley, David
LU
and Hellström-Westas, Lena
LU
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta paediatrica
- volume
- 101
- issue
- 7
- pages
- 719 - 726
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000304715200022
- pmid:22530996
- scopus:84861802748
- pmid:22530996
- ISSN
- 1651-2227
- DOI
- 10.1111/j.1651-2227.2012.02677.x
- language
- English
- LU publication?
- yes
- id
- 1e1e3ffa-28f9-4000-8db1-ff333b834f53 (old id 2519078)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/22530996?dopt=Abstract
- date added to LUP
- 2016-04-04 09:44:21
- date last changed
- 2023-09-20 04:08:27
@article{1e1e3ffa-28f9-4000-8db1-ff333b834f53,
abstract = {{Aim: To characterize early amplitude-integrated electroencephalogram (aEEG) and single-channel EEG (aEEG/EEG) in very preterm (VPT) infants for prediction of long-term outcome. Patients: Forty-nine infants with median (range) gestational age of 25 (22-30) weeks. <br/><br>
<br/><br>
Methods: Amplitude-integrated electroencephalogram/EEG recorded during the first 72 h and analysed over 0-12, 12-24, 24-48 and 48-72 h, for background pattern, sleep-wake cycling, seizures, interburst intervals (IBI) and interburst percentage (IB%). In total, 2614 h of single-channel EEG examined for seizures. Survivors were assessed at 2 years corrected age with a neurological examination and Bayley Scales of Infant Development-II. Poor outcome was defined as death or survival with neurodevelopmental impairment. Good outcome was defined as survival without impairment. <br/><br>
<br/><br>
Results: Thirty infants had good outcome. Poor outcome (n = 19) was associated with depressed aEEG/EEG already during the first 12 h (p = 0.023), and with prolonged IBI and higher IB% at 24 h. Seizures were present in 43% of the infants and associated with intraventricular haemorrhages but not with outcome. Best predictors of poor outcome were burst-suppression pattern [76% correctly predicted; positive predictive value (PPV) 63%, negative predictive value (NPV) 91%], IBI > 6 sec (74% correctly predicted; PPV 67%, NPV 79%) and IB% > 55% at 24 h age (79% correctly predicted; PPV 72%, NPV 80%). In 35 infants with normal cerebral ultrasound during the first 3 days, outcome was correctly predicted in 82% by IB% (PPV 82%, NPV 83%). <br/><br>
<br/><br>
Conclusion: Long-term outcome can be predicted by aEEG/EEG with 75-80% accuracy already at 24 postnatal hours in VPT infants, also in infants with no early indication of brain injury.}},
author = {{Wikström, Sverre and Pupp, Ingrid and Rosén, Ingmar and Norman, Elisabeth and Fellman, Vineta and Ley, David and Hellström-Westas, Lena}},
issn = {{1651-2227}},
language = {{eng}},
number = {{7}},
pages = {{719--726}},
publisher = {{Wiley-Blackwell}},
series = {{Acta paediatrica}},
title = {{Early single-channel aEEG/EEG predicts outcome in very preterm infants.}},
url = {{http://dx.doi.org/10.1111/j.1651-2227.2012.02677.x}},
doi = {{10.1111/j.1651-2227.2012.02677.x}},
volume = {{101}},
year = {{2012}},
}