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A unique 3D endoanal ultrasound feature of perianal Crohn's fistula:the "Crohn ultrasound fistula sign" (CUFS).

Zawadzki, Antoni LU ; Starck-Söndergaard, Marianne LU ; Bohe, Måns LU and Thorlacius, Henrik LU (2012) In Colorectal Disease 14(9). p.608-611
Abstract
Aim: Using a high-resolution 3D endoanal ultrasound, we have observed that some perianal fistulas show a hypoechogenic fistula tract surrounded by a well-defined hyperechogenic area with a thin hypoechogenic edge outside characterized fistulas in patients with Crohn's disease ("Crohn's Ultrasound Fistula Sign" (CUFS)), unlike conventional fistula tracks.. The study aimed to determine the prevalence of CUFS in a consecutive series of patients with anal fistula. Method: 157 patients (median age 45, range 14-86 years,100 males) with perianal fistula were examined with 3D endoanal ultrasound. All 3D volumes were stored and analysed retrospectively by two independent observers blinded to the clinical information of the patients. Results: There... (More)
Aim: Using a high-resolution 3D endoanal ultrasound, we have observed that some perianal fistulas show a hypoechogenic fistula tract surrounded by a well-defined hyperechogenic area with a thin hypoechogenic edge outside characterized fistulas in patients with Crohn's disease ("Crohn's Ultrasound Fistula Sign" (CUFS)), unlike conventional fistula tracks.. The study aimed to determine the prevalence of CUFS in a consecutive series of patients with anal fistula. Method: 157 patients (median age 45, range 14-86 years,100 males) with perianal fistula were examined with 3D endoanal ultrasound. All 3D volumes were stored and analysed retrospectively by two independent observers blinded to the clinical information of the patients. Results: There were 29 patients with Crohn's disease of whom 20 (69%) showed CUFS,. CUFS was absent in 125 (98%) of 128 patients without Crohn's disease. The positive and negative predictive value of CUFS for Crohn's disease was 87% and 93%, respectively. The kappa value of the two independent observers was 0.77, indicating a substantial interobserver agreement. Conclusion: This study provides a new 3D endoanal ultrasound criterion, CUFS, of perianal fistula in patients with Crohn's disease. The sign can be used to discriminate a Crohn's from other types of fistula, which may be useful in the management of patients with anal fistula. © 2012 The Authors Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
perianal fistula, Crohn's disease, 3D ultrasound
in
Colorectal Disease
volume
14
issue
9
pages
608 - 611
publisher
Wiley-Blackwell
external identifiers
  • wos:000307847000014
  • pmid:22507755
  • scopus:84865418011
ISSN
1462-8910
DOI
10.1111/j.1463-1318.2012.03047.x
language
English
LU publication?
yes
id
e4624bf8-1706-416f-ab56-88567008384b (old id 2519375)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22507755?dopt=Abstract
date added to LUP
2012-05-06 17:38:13
date last changed
2017-09-10 03:00:49
@article{e4624bf8-1706-416f-ab56-88567008384b,
  abstract     = {Aim: Using a high-resolution 3D endoanal ultrasound, we have observed that some perianal fistulas show a hypoechogenic fistula tract surrounded by a well-defined hyperechogenic area with a thin hypoechogenic edge outside characterized fistulas in patients with Crohn's disease ("Crohn's Ultrasound Fistula Sign" (CUFS)), unlike conventional fistula tracks.. The study aimed to determine the prevalence of CUFS in a consecutive series of patients with anal fistula. Method: 157 patients (median age 45, range 14-86 years,100 males) with perianal fistula were examined with 3D endoanal ultrasound. All 3D volumes were stored and analysed retrospectively by two independent observers blinded to the clinical information of the patients. Results: There were 29 patients with Crohn's disease of whom 20 (69%) showed CUFS,. CUFS was absent in 125 (98%) of 128 patients without Crohn's disease. The positive and negative predictive value of CUFS for Crohn's disease was 87% and 93%, respectively. The kappa value of the two independent observers was 0.77, indicating a substantial interobserver agreement. Conclusion: This study provides a new 3D endoanal ultrasound criterion, CUFS, of perianal fistula in patients with Crohn's disease. The sign can be used to discriminate a Crohn's from other types of fistula, which may be useful in the management of patients with anal fistula. © 2012 The Authors Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland.},
  author       = {Zawadzki, Antoni and Starck-Söndergaard, Marianne and Bohe, Måns and Thorlacius, Henrik},
  issn         = {1462-8910},
  keyword      = {perianal fistula,Crohn's disease,3D ultrasound},
  language     = {eng},
  number       = {9},
  pages        = {608--611},
  publisher    = {Wiley-Blackwell},
  series       = {Colorectal Disease},
  title        = {A unique 3D endoanal ultrasound feature of perianal Crohn's fistula:the "Crohn ultrasound fistula sign" (CUFS).},
  url          = {http://dx.doi.org/10.1111/j.1463-1318.2012.03047.x},
  volume       = {14},
  year         = {2012},
}