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Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.

Hansen, Christian LU and Li, Jia-Yi LU (2012) In Trends in Molecular Medicine 18(5). p.248-255
Abstract
α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current... (More)
α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current understanding of α-syn toxicity, and how these relate to progression of PD pathology. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Molecular Medicine
volume
18
issue
5
pages
248 - 255
publisher
Elsevier
external identifiers
  • wos:000304232000002
  • pmid:22503115
  • scopus:84860501370
ISSN
1471-4914
DOI
10.1016/j.molmed.2012.03.002
language
English
LU publication?
yes
id
816abdf2-46b0-44c5-9562-878b09f3c770 (old id 2519440)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/22503115?dopt=Abstract
date added to LUP
2012-05-06 17:50:32
date last changed
2017-10-29 03:58:33
@article{816abdf2-46b0-44c5-9562-878b09f3c770,
  abstract     = {α-Synuclein (α-syn) is the most abundant protein found in Lewy bodies, a hallmark of Parkinson's disease (PD), and can aggregate to form toxic oligomers and fibrillar structures. Recent studies have shown that α-syn can be transmitted between neurons and can seed the formation of toxic aggregates in recipient neurons in a prion-like manner. In addition, it is known that Lewy body pathology may spread gradually and systematically from the peripheral or enteric nervous system or olfactory bulb to specific brain regions during progression of idiopathic PD. It is therefore conceivable that α-syn species could act as seeds that drive PD progression. Here, we review recent advances from studies of α-syn cell-to-cell transfer, the current understanding of α-syn toxicity, and how these relate to progression of PD pathology.},
  author       = {Hansen, Christian and Li, Jia-Yi},
  issn         = {1471-4914},
  language     = {eng},
  number       = {5},
  pages        = {248--255},
  publisher    = {Elsevier},
  series       = {Trends in Molecular Medicine},
  title        = {Beyond α-synuclein transfer: pathology propagation in Parkinson's disease.},
  url          = {http://dx.doi.org/10.1016/j.molmed.2012.03.002},
  volume       = {18},
  year         = {2012},
}