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Analysis of the surface electrocardiogram for monitoring and predicting antiarrhythmic drug effects in atrial fibrillation

Husser, D; Stridh, Martin LU ; Sörnmo, Leif LU ; Platonov, Pyotr LU ; Olsson, Bertil LU and Bollmann, Andreas LU (2004) In Cardiovascular Drugs and Therapy 18(5). p.377-386
Abstract
Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical setting it is difficult to directly evaluate the effects of antiarrhythmic drugs on the individual patient's atrial electrophysiology, thereby predicting their efficacy in restoring and maintaining sinus rhythm. Analysis of the surface electrocardiogram in terms of P-wave signal averaged ECG during sinus rhythm and spectral characterization of fibrillatory waves during AF for evaluation of atrial antiarrhythmic drug effects is a... (More)
Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical setting it is difficult to directly evaluate the effects of antiarrhythmic drugs on the individual patient's atrial electrophysiology, thereby predicting their efficacy in restoring and maintaining sinus rhythm. Analysis of the surface electrocardiogram in terms of P-wave signal averaged ECG during sinus rhythm and spectral characterization of fibrillatory waves during AF for evaluation of atrial antiarrhythmic drug effects is a new field of investigation. Both techniques provide reproducible parameters for characterizing atrial electrical abnormalities and seem to contain prognostic information regarding antiarrhythmic drug efficacy. Further research is needed which elucidates the most challenging clinical questions in AF management whom to place on antiarrhythmic drug treatment and what antiarrhythmic drug to prescribe. Analysis of the surface ECG might have the potential to answer these questions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
antiarrhythmic drugs, electrical remodeling, atrial fibrillation, ECG, drug monitoring
in
Cardiovascular Drugs and Therapy
volume
18
issue
5
pages
377 - 386
publisher
Springer
external identifiers
  • wos:000226981900007
  • pmid:15717140
  • scopus:17644411108
ISSN
0920-3206
DOI
10.1007/s10557-005-5062-z
language
English
LU publication?
yes
id
2e9fe8d5-1d54-4cad-9520-5c2ce3076dc4 (old id 253822)
date added to LUP
2007-08-02 15:48:34
date last changed
2017-08-27 05:41:21
@article{2e9fe8d5-1d54-4cad-9520-5c2ce3076dc4,
  abstract     = {Specific antiarrhythmic therapy with class I and III drugs for atrial fibrillation (AF) conversion and prevention of its recurrence is frequently utilized in clinical practice. Besides being only moderate effective, the utilization of antiarrhythmic drugs may be associated with serious side effects. In the clinical setting it is difficult to directly evaluate the effects of antiarrhythmic drugs on the individual patient's atrial electrophysiology, thereby predicting their efficacy in restoring and maintaining sinus rhythm. Analysis of the surface electrocardiogram in terms of P-wave signal averaged ECG during sinus rhythm and spectral characterization of fibrillatory waves during AF for evaluation of atrial antiarrhythmic drug effects is a new field of investigation. Both techniques provide reproducible parameters for characterizing atrial electrical abnormalities and seem to contain prognostic information regarding antiarrhythmic drug efficacy. Further research is needed which elucidates the most challenging clinical questions in AF management whom to place on antiarrhythmic drug treatment and what antiarrhythmic drug to prescribe. Analysis of the surface ECG might have the potential to answer these questions.},
  author       = {Husser, D and Stridh, Martin and Sörnmo, Leif and Platonov, Pyotr and Olsson, Bertil and Bollmann, Andreas},
  issn         = {0920-3206},
  keyword      = {antiarrhythmic drugs,electrical remodeling,atrial fibrillation,ECG,drug monitoring},
  language     = {eng},
  number       = {5},
  pages        = {377--386},
  publisher    = {Springer},
  series       = {Cardiovascular Drugs and Therapy},
  title        = {Analysis of the surface electrocardiogram for monitoring and predicting antiarrhythmic drug effects in atrial fibrillation},
  url          = {http://dx.doi.org/10.1007/s10557-005-5062-z},
  volume       = {18},
  year         = {2004},
}