Time-resolved NIR spectroscopy for quantitative analysis of intact pharmaceutical tablets
(2005) In Analytical Chemistry 77(4). p.1055-1059- Abstract
- Near-infrared (NIR) spectroscopy is a useful technique for quantitative measurements of intact tablets, but it suffers from limitations due to the fact that changes in the physical properties of a sample strongly affect the recorded spectrum. In this work, time-resolved transmission NIR spectroscopy was utilized to conduct quantitative measurements of intact tablets. The technique enables separation of the absorption properties of the sample from the scattering properties and can therefore handle changes of the physical parameters of the samples in a better way than conventional NIR transmission spectroscopy. The experiments were conducted using a pulsed Ti:sapphire laser coupled into a nonlinear photonic crystal fiber as light source. The... (More)
- Near-infrared (NIR) spectroscopy is a useful technique for quantitative measurements of intact tablets, but it suffers from limitations due to the fact that changes in the physical properties of a sample strongly affect the recorded spectrum. In this work, time-resolved transmission NIR spectroscopy was utilized to conduct quantitative measurements of intact tablets. The technique enables separation of the absorption properties of the sample from the scattering properties and can therefore handle changes of the physical parameters of the samples in a better way than conventional NIR transmission spectroscopy. The experiments were conducted using a pulsed Ti:sapphire laser coupled into a nonlinear photonic crystal fiber as light source. The light transmitted through the sample was measured by a time-resolving streak camera. A comparison of the results from the time-resolved technique with the results from conventional transmission NIR spectroscopy was made using tablets containing different concentrations of iron oxide and manufactured with different thicknesses. A PLS model made with data from the time-resolved technique predicted samples 5 times better than a PLS model made data from the conventional NIR transmission technique. Furthermore, an improvement to predict samples with physical properties outside those included in the calibration set was demonstrated. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/253946
- author
- Abrahamsson, Christoffer LU ; Johansson, J ; Andersson-Engels, Stefan LU ; Svanberg, Sune LU and Folestad, S
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Analytical Chemistry
- volume
- 77
- issue
- 4
- pages
- 1055 - 1059
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- wos:000227111200013
- scopus:13844315677
- ISSN
- 1520-6882
- DOI
- 10.1021/ac0487754
- language
- English
- LU publication?
- yes
- id
- 49c8c90b-10ea-4268-aaea-5e0b728dad19 (old id 253946)
- date added to LUP
- 2016-04-01 12:27:14
- date last changed
- 2022-01-27 03:55:12
@article{49c8c90b-10ea-4268-aaea-5e0b728dad19,
abstract = {{Near-infrared (NIR) spectroscopy is a useful technique for quantitative measurements of intact tablets, but it suffers from limitations due to the fact that changes in the physical properties of a sample strongly affect the recorded spectrum. In this work, time-resolved transmission NIR spectroscopy was utilized to conduct quantitative measurements of intact tablets. The technique enables separation of the absorption properties of the sample from the scattering properties and can therefore handle changes of the physical parameters of the samples in a better way than conventional NIR transmission spectroscopy. The experiments were conducted using a pulsed Ti:sapphire laser coupled into a nonlinear photonic crystal fiber as light source. The light transmitted through the sample was measured by a time-resolving streak camera. A comparison of the results from the time-resolved technique with the results from conventional transmission NIR spectroscopy was made using tablets containing different concentrations of iron oxide and manufactured with different thicknesses. A PLS model made with data from the time-resolved technique predicted samples 5 times better than a PLS model made data from the conventional NIR transmission technique. Furthermore, an improvement to predict samples with physical properties outside those included in the calibration set was demonstrated.}},
author = {{Abrahamsson, Christoffer and Johansson, J and Andersson-Engels, Stefan and Svanberg, Sune and Folestad, S}},
issn = {{1520-6882}},
language = {{eng}},
number = {{4}},
pages = {{1055--1059}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Analytical Chemistry}},
title = {{Time-resolved NIR spectroscopy for quantitative analysis of intact pharmaceutical tablets}},
url = {{https://lup.lub.lu.se/search/files/2929944/2368817.pdf}},
doi = {{10.1021/ac0487754}},
volume = {{77}},
year = {{2005}},
}