Advanced

Craniofacial dysmorphology in Swedish schizophrenia patients

Kelly, B D; Lane, A; Agartz, I; Henriksson, Karin LU and McNeil, Thomas LU (2005) In Acta Psychiatrica Scandinavica 111(3). p.202-207
Abstract
Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and... (More)
Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and patient/control status. Conclusion: The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose-response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
schizophrenia, aetiology, human development
in
Acta Psychiatrica Scandinavica
volume
111
issue
3
pages
202 - 207
publisher
Wiley-Blackwell
external identifiers
  • wos:000226899500006
  • pmid:15701104
  • scopus:14844291375
ISSN
1600-0447
DOI
10.1111/j.1600-0447.2004.00473.x
language
English
LU publication?
yes
id
d129a152-0150-4bf6-be60-86591a150a75 (old id 253987)
date added to LUP
2007-08-07 14:51:31
date last changed
2017-10-22 04:43:59
@article{d129a152-0150-4bf6-be60-86591a150a75,
  abstract     = {Objective: To perform detailed assessments of craniofacial dysmorphology in individuals with schizophrenia and controls in Sweden, in order to further elucidate the neurodevelopmental origins of schizophrenia. Method: We performed detailed, anthropometric assessments of craniofacial dysmorphology in male patients with schizophrenia (n = 24), healthy controls (n = 16), and patients' siblings with schizophrenia (n = 2) in Sweden, while remaining as blind as possible to schizophrenia/control status. Results: Individuals with schizophrenia evidenced significantly more craniofacial dysmorphology than controls, especially in the ears and mouth. At a group level, there was a dose-response type relationship between total dysmorphology score and patient/control status. Conclusion: The consistency of results across multiple studies supports the hypothesis that individuals with schizophrenia have increased rates of prenatal developmental disturbances. The presence of a dose-response type relationship between total dysmorphology score and patient/control status supports the importance of neurodevelopmental disturbance as a contributory cause of schizophrenia.},
  author       = {Kelly, B D and Lane, A and Agartz, I and Henriksson, Karin and McNeil, Thomas},
  issn         = {1600-0447},
  keyword      = {schizophrenia,aetiology,human development},
  language     = {eng},
  number       = {3},
  pages        = {202--207},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Psychiatrica Scandinavica},
  title        = {Craniofacial dysmorphology in Swedish schizophrenia patients},
  url          = {http://dx.doi.org/10.1111/j.1600-0447.2004.00473.x},
  volume       = {111},
  year         = {2005},
}