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Raised serum S100B levels after acute bone fractures without cerebral injury

Undén, Johan LU ; Bellner, Johan LU ; Eneroth, Magnus LU ; Alling, Christer LU ; Ingebrigtsen, T and Romner, Bertil LU (2005) In Journal of Trauma 58(1). p.59-61
Abstract
Background: S100B, a protein abundant in astroglial cells within the central nervous system, has been shown to increase in cerebrospinal fluid and serum after various neurologic diseases. However, the cerebral specificity of S100B has been questioned. This study aims to show serum S100B levels after uncomplicated bone fractures in patients without current or prior neurologic diseases. Methods: Blood for sampling was drawn from patients seeking care at the emergency department presenting with various uncomplicated orthopedic fractures no older than 24 hours and having no previous or suspected neurologic disorder or head injury. Results: Fifty-five consecutive patients with acute fractures were included in the study. Serum S100B levels were... (More)
Background: S100B, a protein abundant in astroglial cells within the central nervous system, has been shown to increase in cerebrospinal fluid and serum after various neurologic diseases. However, the cerebral specificity of S100B has been questioned. This study aims to show serum S100B levels after uncomplicated bone fractures in patients without current or prior neurologic diseases. Methods: Blood for sampling was drawn from patients seeking care at the emergency department presenting with various uncomplicated orthopedic fractures no older than 24 hours and having no previous or suspected neurologic disorder or head injury. Results: Fifty-five consecutive patients with acute fractures were included in the study. Serum S100B levels were raised above 0.15 mug/L in 16 of 55 (29%) patients (range, 0.02-0.51 mug/L; mean, 0.13 +/- 0.11 mug/L). Conclusion: S100B levels were raised in 29% of patients with acute fractures without apparent cerebral injury, which suggests an extracerebral source of S100B. This information should be taken into account when interpreting S100B levels when dealing with brain damage. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
marker, S100B, extracerebral, brain, damage
in
Journal of Trauma
volume
58
issue
1
pages
59 - 61
publisher
Lippincott Williams and Wilkins
external identifiers
  • wos:000226782300011
  • scopus:13544277551
ISSN
0022-5282
DOI
10.1097/01.TA.0000130613.35877.75
language
English
LU publication?
yes
id
86448a46-f1c6-4ca3-9a60-28ce38c2262f (old id 254261)
date added to LUP
2007-08-23 18:21:53
date last changed
2017-11-19 04:11:05
@article{86448a46-f1c6-4ca3-9a60-28ce38c2262f,
  abstract     = {Background: S100B, a protein abundant in astroglial cells within the central nervous system, has been shown to increase in cerebrospinal fluid and serum after various neurologic diseases. However, the cerebral specificity of S100B has been questioned. This study aims to show serum S100B levels after uncomplicated bone fractures in patients without current or prior neurologic diseases. Methods: Blood for sampling was drawn from patients seeking care at the emergency department presenting with various uncomplicated orthopedic fractures no older than 24 hours and having no previous or suspected neurologic disorder or head injury. Results: Fifty-five consecutive patients with acute fractures were included in the study. Serum S100B levels were raised above 0.15 mug/L in 16 of 55 (29%) patients (range, 0.02-0.51 mug/L; mean, 0.13 +/- 0.11 mug/L). Conclusion: S100B levels were raised in 29% of patients with acute fractures without apparent cerebral injury, which suggests an extracerebral source of S100B. This information should be taken into account when interpreting S100B levels when dealing with brain damage.},
  author       = {Undén, Johan and Bellner, Johan and Eneroth, Magnus and Alling, Christer and Ingebrigtsen, T and Romner, Bertil},
  issn         = {0022-5282},
  keyword      = {marker,S100B,extracerebral,brain,damage},
  language     = {eng},
  number       = {1},
  pages        = {59--61},
  publisher    = {Lippincott Williams and Wilkins},
  series       = {Journal of Trauma},
  title        = {Raised serum S100B levels after acute bone fractures without cerebral injury},
  url          = {http://dx.doi.org/10.1097/01.TA.0000130613.35877.75},
  volume       = {58},
  year         = {2005},
}