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Interaction between isoniazid and theophylline

Höglund, P LU ; Nilsson, L G and Paulsen, Otto (1987) In European Journal of Respiratory Diseases 70(2). p.6-110
Abstract

Metabolic interactions between theophylline and several other drugs have been described in a number of studies. They may be of importance because of the narrow therapeutic range of theophylline. A significant risk for interactions has been considered to exist only with drugs metabolized by oxidative enzyme systems, and thus is not expected to occur with isoniazid. However, an increased clearance of theophylline with oral isoniazid medication has been reported. On the other hand, we found a significant increase in plasma levels of intravenously infused theophylline, and a corresponding decrease in plasma clearance of theophylline, when isoniazid was administered orally, compared to similar infusions in these individuals without... (More)

Metabolic interactions between theophylline and several other drugs have been described in a number of studies. They may be of importance because of the narrow therapeutic range of theophylline. A significant risk for interactions has been considered to exist only with drugs metabolized by oxidative enzyme systems, and thus is not expected to occur with isoniazid. However, an increased clearance of theophylline with oral isoniazid medication has been reported. On the other hand, we found a significant increase in plasma levels of intravenously infused theophylline, and a corresponding decrease in plasma clearance of theophylline, when isoniazid was administered orally, compared to similar infusions in these individuals without concomitant isoniazid medication. The effect was seen irrespective of acetylator status. In five of the seven subjects an increase of isoniazid half-life and AUC was seen with theophylline, but this increase was not statistically significant.

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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Acetylation, Adult, Drug Interactions, Female, Humans, Isoniazid, Kinetics, Male, Middle Aged, Theophylline, Journal Article
in
European Journal of Respiratory Diseases
volume
70
issue
2
pages
6 - 110
publisher
Munksgaard International Publishers
external identifiers
  • scopus:0023102624
ISSN
0106-4339
language
English
LU publication?
yes
id
254428bf-1ec0-4648-b74c-ce8a57c4e82d
date added to LUP
2017-09-14 23:49:39
date last changed
2017-09-19 16:04:15
@article{254428bf-1ec0-4648-b74c-ce8a57c4e82d,
  abstract     = {<p>Metabolic interactions between theophylline and several other drugs have been described in a number of studies. They may be of importance because of the narrow therapeutic range of theophylline. A significant risk for interactions has been considered to exist only with drugs metabolized by oxidative enzyme systems, and thus is not expected to occur with isoniazid. However, an increased clearance of theophylline with oral isoniazid medication has been reported. On the other hand, we found a significant increase in plasma levels of intravenously infused theophylline, and a corresponding decrease in plasma clearance of theophylline, when isoniazid was administered orally, compared to similar infusions in these individuals without concomitant isoniazid medication. The effect was seen irrespective of acetylator status. In five of the seven subjects an increase of isoniazid half-life and AUC was seen with theophylline, but this increase was not statistically significant.</p>},
  author       = {Höglund, P and Nilsson, L G and Paulsen, Otto},
  issn         = {0106-4339},
  keyword      = {Acetylation,Adult,Drug Interactions,Female,Humans,Isoniazid,Kinetics,Male,Middle Aged,Theophylline,Journal Article},
  language     = {eng},
  number       = {2},
  pages        = {6--110},
  publisher    = {Munksgaard International Publishers},
  series       = {European Journal of Respiratory Diseases},
  title        = {Interaction between isoniazid and theophylline},
  volume       = {70},
  year         = {1987},
}