Proposed core set of outcome measures in patients with primary Sjögren's syndrome: 5 year follow up.
(2005) In Journal of Rheumatology 32(8). p.1495-1502- Abstract
- Objective. To clarify the spontaneous course of important disease manifestations (a core set of outcome measures) over a period of 5 years in patients with primary Sjögren's syndrome (SS), and to analyze predictors of unfavorable outcome. To test the usefulness of the recently proposed core set of outcome measures.
Methods. A cohort of patients with primary SS according to the American-European consensus criteria (AECC) (n = 58) was followed over a period of 5 years. Measures for subjective and objective disease characteristics, IgG concentrations and health related quality of life were analyzed on 2 occasions and compared.
Results. During followup, symptoms of dry eyes, dry mouth, fatigue, and health... (More) - Objective. To clarify the spontaneous course of important disease manifestations (a core set of outcome measures) over a period of 5 years in patients with primary Sjögren's syndrome (SS), and to analyze predictors of unfavorable outcome. To test the usefulness of the recently proposed core set of outcome measures.
Methods. A cohort of patients with primary SS according to the American-European consensus criteria (AECC) (n = 58) was followed over a period of 5 years. Measures for subjective and objective disease characteristics, IgG concentrations and health related quality of life were analyzed on 2 occasions and compared.
Results. During followup, symptoms of dry eyes, dry mouth, fatigue, and health related quality of life were stable. Regarding objective signs, there was a modest but statistically significant worsening of the van Bijsterveld score. Seropositivity for anti-SSA and low complement levels predicted further decline in the van Bijsterveld score. Floor/ceiling effects in the outcome measures in the core set complicate documentation of further decline, but may allow monitoring of improvement in established primary SS.
Conclusion. Primary SS, if classified according to the strict AECC criteria, is a bothersome and slowly progressive disease, with fatigue and discomfort developing early. The proposed outcome measures may be suitable for assessing improvement in randomized controlled trials. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/142986
- author
- Theander, Elke LU ; Andersson, Sven Ingmar LU ; Manthorpe, Rolf LU and Jacobsson, Lennart LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Rheumatology
- volume
- 32
- issue
- 8
- pages
- 1495 - 1502
- publisher
- Journal of Rheumatology Publishing Company Limited
- external identifiers
-
- pmid:16078325
- wos:000231103100014
- scopus:23444452578
- ISSN
- 0315-162X
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Psychology (012010000), Emergency medicine/Medicine/Surgery (013240200), Department of Rheumatology (013036000), Internal Medicine Research Unit (013242520)
- id
- 2547b2c3-42d7-495c-b6e2-55a247d3b6e3 (old id 142986)
- alternative location
- http://www.jrheum.com/subscribers/05/08/1495.html
- date added to LUP
- 2016-04-01 12:04:00
- date last changed
- 2022-04-21 01:58:19
@article{2547b2c3-42d7-495c-b6e2-55a247d3b6e3,
abstract = {{Objective. To clarify the spontaneous course of important disease manifestations (a core set of outcome measures) over a period of 5 years in patients with primary Sjögren's syndrome (SS), and to analyze predictors of unfavorable outcome. To test the usefulness of the recently proposed core set of outcome measures.<br/><br>
<br/><br>
Methods. A cohort of patients with primary SS according to the American-European consensus criteria (AECC) (n = 58) was followed over a period of 5 years. Measures for subjective and objective disease characteristics, IgG concentrations and health related quality of life were analyzed on 2 occasions and compared.<br/><br>
<br/><br>
Results. During followup, symptoms of dry eyes, dry mouth, fatigue, and health related quality of life were stable. Regarding objective signs, there was a modest but statistically significant worsening of the van Bijsterveld score. Seropositivity for anti-SSA and low complement levels predicted further decline in the van Bijsterveld score. Floor/ceiling effects in the outcome measures in the core set complicate documentation of further decline, but may allow monitoring of improvement in established primary SS.<br/><br>
<br/><br>
Conclusion. Primary SS, if classified according to the strict AECC criteria, is a bothersome and slowly progressive disease, with fatigue and discomfort developing early. The proposed outcome measures may be suitable for assessing improvement in randomized controlled trials.}},
author = {{Theander, Elke and Andersson, Sven Ingmar and Manthorpe, Rolf and Jacobsson, Lennart}},
issn = {{0315-162X}},
language = {{eng}},
number = {{8}},
pages = {{1495--1502}},
publisher = {{Journal of Rheumatology Publishing Company Limited}},
series = {{Journal of Rheumatology}},
title = {{Proposed core set of outcome measures in patients with primary Sjögren's syndrome: 5 year follow up.}},
url = {{http://www.jrheum.com/subscribers/05/08/1495.html}},
volume = {{32}},
year = {{2005}},
}