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Mid-Thigh Cortical Bone Structural Parameters, Muscle Mass and Strength, and Association with Lower Limb Fractures in Older Men and Women (AGES-Reykjavik Study)

Johannesdottir, Fjola; Aspelund, Thor; Siggeirsdottir, Kristin; Jonsson, Brynjolfur LU ; Mogensen, Brynjolfur; Sigurdsson, Sigurdur; Harris, Tamara B.; Gudnason, Vilmundur G.; Lang, Thomas F. and Sigurdsson, Gunnar (2012) In Calcified Tissue International 90(5). p.354-364
Abstract
In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained < 10 % of variability in those bone... (More)
In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained < 10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Mid-thigh, Muscle-bone relationship, Aging, Fracture risk, CT
in
Calcified Tissue International
volume
90
issue
5
pages
354 - 364
publisher
Springer
external identifiers
  • wos:000303017300002
  • scopus:84859919236
ISSN
1432-0827
DOI
10.1007/s00223-012-9585-6
language
English
LU publication?
yes
id
82a70347-6a4f-4917-a2b7-04a3336e4c6c (old id 2563075)
date added to LUP
2012-06-01 08:43:20
date last changed
2017-06-11 04:19:50
@article{82a70347-6a4f-4917-a2b7-04a3336e4c6c,
  abstract     = {In a cross-sectional study we investigated the relationship between muscle and bone parameters in the mid-thigh in older people using data from a single axial computed tomographic section through the mid-thigh. Additionally, we studied the association of these variables with incident low-trauma lower limb fractures. A total of 3,762 older individuals (1,838 men and 1,924 women), aged 66-96 years, participants in the AGES-Reykjavik study, were studied. The total cross-sectional muscular area and knee extensor strength declined with age similarly in both sexes. Muscle parameters correlated most strongly with cortical area and total shaft area (adjusted for age, height, and weight) but explained &lt; 10 % of variability in those bone parameters. The increment in medullary area (MA) and buckling ratio (BR) with age was almost fourfold greater in women than men. The association between MA and muscle parameters was nonsignificant. During a median follow-up of 5.3 years, 113 women and 66 men sustained incident lower limb fractures. Small muscular area, low knee extensor strength, large MA, low cortical thickness, and high BR were significantly associated with fractures in both sexes. Our results show that bone and muscle loss proceed at different rates and with different gender patterns.},
  author       = {Johannesdottir, Fjola and Aspelund, Thor and Siggeirsdottir, Kristin and Jonsson, Brynjolfur and Mogensen, Brynjolfur and Sigurdsson, Sigurdur and Harris, Tamara B. and Gudnason, Vilmundur G. and Lang, Thomas F. and Sigurdsson, Gunnar},
  issn         = {1432-0827},
  keyword      = {Mid-thigh,Muscle-bone relationship,Aging,Fracture risk,CT},
  language     = {eng},
  number       = {5},
  pages        = {354--364},
  publisher    = {Springer},
  series       = {Calcified Tissue International},
  title        = {Mid-Thigh Cortical Bone Structural Parameters, Muscle Mass and Strength, and Association with Lower Limb Fractures in Older Men and Women (AGES-Reykjavik Study)},
  url          = {http://dx.doi.org/10.1007/s00223-012-9585-6},
  volume       = {90},
  year         = {2012},
}