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Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can)

Ulmer, Hanno; Bjorge, Tone; Concin, Hans; Lukanova, Annekatrin; Manjer, Jonas LU ; Hallmans, Goran; Borena, Wegene; Haggstrom, Christel; Engeland, Anders and Almquist, Martin LU , et al. (2012) In Gynecologic Oncology 125(2). p.330-335
Abstract
Background. Little is known about the association between metabolic risk factors and cervical cancer carcinogenesis. Material and methods. During mean follow-up of 11 years of the Me-Can cohort (N = 288,834) 425 invasive cervical cancer cases were diagnosed. Hazard ratios (HRs) were estimated by the use of Cox proportional hazards regression models for quintiles and standardized z-scores (with a mean of 0 and a SD of 1) of BMI, blood pressure, glucose, cholesterol, triglycerides and MetS score. Risk estimates were corrected for random error in the measurements. Results. BMI (per 1SD increment) was associated with 12%, increase of cervical cancer risk, blood pressure with 25% and triglycerides with 39%, respectively. In models including all... (More)
Background. Little is known about the association between metabolic risk factors and cervical cancer carcinogenesis. Material and methods. During mean follow-up of 11 years of the Me-Can cohort (N = 288,834) 425 invasive cervical cancer cases were diagnosed. Hazard ratios (HRs) were estimated by the use of Cox proportional hazards regression models for quintiles and standardized z-scores (with a mean of 0 and a SD of 1) of BMI, blood pressure, glucose, cholesterol, triglycerides and MetS score. Risk estimates were corrected for random error in the measurements. Results. BMI (per 1SD increment) was associated with 12%, increase of cervical cancer risk, blood pressure with 25% and triglycerides with 39%, respectively. In models including all metabolic factors, the associations for blood pressure and triglycerides persisted. The metabolic syndrome (MetS) score was associated with 26% increased corrected risk of cervical cancer. Triglycerides were stronger associated with squamous cell carcinoma (HR 1.48; 95% CI, 1.20-1.83) than with adenocarcinoma (0.92, 0.54-1.56). Among older women cholesterol (50-70 years 1.34; 1.00-1.81), triglycerides (50-70 years 1.49, 1.03-2.16 and >= 70 years 1.54, 1.09-2.19) and glucose (>= 70 years 1.87, 1.13-3.11) were associated with increased cervical cancer risk. Conclusion. The presence of obesity, elevated blood pressure and triglycerides were associated with increased risk of cervical cancer. (C) 2012 Elsevier Inc. All rights reserved. (Less)
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published
subject
keywords
Metabolic factors, Cervical cancer, Epidemiology, CONOR
in
Gynecologic Oncology
volume
125
issue
2
pages
330 - 335
publisher
Academic Press
external identifiers
  • wos:000303227500011
  • scopus:84859616958
ISSN
1095-6859
DOI
10.1016/j.ygyno.2012.01.052
language
English
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yes
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27c6bfa3-37d6-49df-aa49-d8c6d5a49fec (old id 2563208)
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2012-06-01 08:48:41
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2017-08-13 03:09:27
@article{27c6bfa3-37d6-49df-aa49-d8c6d5a49fec,
  abstract     = {Background. Little is known about the association between metabolic risk factors and cervical cancer carcinogenesis. Material and methods. During mean follow-up of 11 years of the Me-Can cohort (N = 288,834) 425 invasive cervical cancer cases were diagnosed. Hazard ratios (HRs) were estimated by the use of Cox proportional hazards regression models for quintiles and standardized z-scores (with a mean of 0 and a SD of 1) of BMI, blood pressure, glucose, cholesterol, triglycerides and MetS score. Risk estimates were corrected for random error in the measurements. Results. BMI (per 1SD increment) was associated with 12%, increase of cervical cancer risk, blood pressure with 25% and triglycerides with 39%, respectively. In models including all metabolic factors, the associations for blood pressure and triglycerides persisted. The metabolic syndrome (MetS) score was associated with 26% increased corrected risk of cervical cancer. Triglycerides were stronger associated with squamous cell carcinoma (HR 1.48; 95% CI, 1.20-1.83) than with adenocarcinoma (0.92, 0.54-1.56). Among older women cholesterol (50-70 years 1.34; 1.00-1.81), triglycerides (50-70 years 1.49, 1.03-2.16 and >= 70 years 1.54, 1.09-2.19) and glucose (>= 70 years 1.87, 1.13-3.11) were associated with increased cervical cancer risk. Conclusion. The presence of obesity, elevated blood pressure and triglycerides were associated with increased risk of cervical cancer. (C) 2012 Elsevier Inc. All rights reserved.},
  author       = {Ulmer, Hanno and Bjorge, Tone and Concin, Hans and Lukanova, Annekatrin and Manjer, Jonas and Hallmans, Goran and Borena, Wegene and Haggstrom, Christel and Engeland, Anders and Almquist, Martin and Jonsson, Hakan and Selmer, Randi and Stattin, Par and Tretli, Steinar and Kleiner, Andrea and Stocks, Tanja and Nagel, Gabriele},
  issn         = {1095-6859},
  keyword      = {Metabolic factors,Cervical cancer,Epidemiology,CONOR},
  language     = {eng},
  number       = {2},
  pages        = {330--335},
  publisher    = {Academic Press},
  series       = {Gynecologic Oncology},
  title        = {Metabolic risk factors and cervical cancer in the metabolic syndrome and cancer project (Me-Can)},
  url          = {http://dx.doi.org/10.1016/j.ygyno.2012.01.052},
  volume       = {125},
  year         = {2012},
}