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Posterior Insular Molecular Changes in Myofascial Pain

Gerstner, G. E.; Gracely, R. H.; Deebajah, A.; Ichesco, E.; Quintero, A.; Clauw, D. J. and Sundgren, Pia LU (2012) In Journal of Dental Research 91(5). p.485-490
Abstract
Temporomandibular disorders (TMD) include craniocervical pain conditions with unclear etiologies. Central changes are suspected; however, few neuroimaging studies of TMD exist. Single-voxel proton magnetic resonance spectroscopy (H-1-MRS) was used before and after pressure-pain testing to assess glutamate (Glu), glutamine (Gln), N-acetylaspartate (NAA), and choline (Cho) levels in the right and left posterior insulae of 11 individuals with myofascial TMD and 11 matched control individuals. Glu levels were significantly lower in all individuals after pain testing. Among those with TMD, left-insular Gln levels were related to reported pain, left posterior insular NAA and Cho levels were significantly higher at baseline than in control... (More)
Temporomandibular disorders (TMD) include craniocervical pain conditions with unclear etiologies. Central changes are suspected; however, few neuroimaging studies of TMD exist. Single-voxel proton magnetic resonance spectroscopy (H-1-MRS) was used before and after pressure-pain testing to assess glutamate (Glu), glutamine (Gln), N-acetylaspartate (NAA), and choline (Cho) levels in the right and left posterior insulae of 11 individuals with myofascial TMD and 11 matched control individuals. Glu levels were significantly lower in all individuals after pain testing. Among those with TMD, left-insular Gln levels were related to reported pain, left posterior insular NAA and Cho levels were significantly higher at baseline than in control individuals, and NAA levels were significantly correlated with pain-symptom duration, suggesting adaptive changes. The results suggest that significant central cellular and molecular changes can occur in individuals with TMD. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
magnetic resonance spectroscopy, temporomandibular disorders, N-acetyl, aspartate, choline, glutamate, glutamine
in
Journal of Dental Research
volume
91
issue
5
pages
485 - 490
publisher
International & American Associations for Dental Research
external identifiers
  • wos:000302916300009
  • scopus:84859899301
ISSN
0022-0345
DOI
10.1177/0022034512443366
language
English
LU publication?
yes
id
135abdf8-2bb0-43c6-aa36-fc577ce8d7ef (old id 2570914)
date added to LUP
2012-06-01 08:52:21
date last changed
2017-06-04 03:14:14
@article{135abdf8-2bb0-43c6-aa36-fc577ce8d7ef,
  abstract     = {Temporomandibular disorders (TMD) include craniocervical pain conditions with unclear etiologies. Central changes are suspected; however, few neuroimaging studies of TMD exist. Single-voxel proton magnetic resonance spectroscopy (H-1-MRS) was used before and after pressure-pain testing to assess glutamate (Glu), glutamine (Gln), N-acetylaspartate (NAA), and choline (Cho) levels in the right and left posterior insulae of 11 individuals with myofascial TMD and 11 matched control individuals. Glu levels were significantly lower in all individuals after pain testing. Among those with TMD, left-insular Gln levels were related to reported pain, left posterior insular NAA and Cho levels were significantly higher at baseline than in control individuals, and NAA levels were significantly correlated with pain-symptom duration, suggesting adaptive changes. The results suggest that significant central cellular and molecular changes can occur in individuals with TMD.},
  author       = {Gerstner, G. E. and Gracely, R. H. and Deebajah, A. and Ichesco, E. and Quintero, A. and Clauw, D. J. and Sundgren, Pia},
  issn         = {0022-0345},
  keyword      = {magnetic resonance spectroscopy,temporomandibular disorders,N-acetyl,aspartate,choline,glutamate,glutamine},
  language     = {eng},
  number       = {5},
  pages        = {485--490},
  publisher    = {International & American Associations for Dental Research},
  series       = {Journal of Dental Research},
  title        = {Posterior Insular Molecular Changes in Myofascial Pain},
  url          = {http://dx.doi.org/10.1177/0022034512443366},
  volume       = {91},
  year         = {2012},
}