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7-T MR-from research to clinical applications?

Moser, Ewald; Ståhlberg, Freddy LU ; Ladd, Mark E. and Trattnig, Siegfried (2012) In NMR in Biomedicine 25(5). p.695-716
Abstract
Over 20?000 MR systems are currently installed worldwide and, although the majority operate at magnetic fields of 1.5?T and below (i.e. about 70%), experience with 3-T (in high-field clinical diagnostic imaging and research) and 7-T (research only) human MR scanners points to a future in functional and metabolic MR diagnostics. Complementary to previous studies, this review attempts to provide an overview of ultrahigh-field MR research with special emphasis on emerging clinical applications at 7?T. We provide a short summary of the technical development and the current status of installed MR systems. The advantages and challenges of ultrahigh-field MRI and MRS are discussed with special emphasis on radiofrequency inhomogeneity, relaxation... (More)
Over 20?000 MR systems are currently installed worldwide and, although the majority operate at magnetic fields of 1.5?T and below (i.e. about 70%), experience with 3-T (in high-field clinical diagnostic imaging and research) and 7-T (research only) human MR scanners points to a future in functional and metabolic MR diagnostics. Complementary to previous studies, this review attempts to provide an overview of ultrahigh-field MR research with special emphasis on emerging clinical applications at 7?T. We provide a short summary of the technical development and the current status of installed MR systems. The advantages and challenges of ultrahigh-field MRI and MRS are discussed with special emphasis on radiofrequency inhomogeneity, relaxation times, signal-to-noise improvements, susceptibility effects, chemical shifts, specific absorption rate and other safety issues. In terms of applications, we focus on the topics most likely to gain significantly from 7-T MR, i.e. brain imaging and spectroscopy and musculoskeletal imaging, but also body imaging, which is particularly challenging. Examples are given to demonstrate the advantages of susceptibility-weighted imaging, time-of-flight MR angiography, high-resolution functional MRI, 1H and 31P MRSI in the human brain, sodium and functional imaging of cartilage and the first results (and artefacts) using an eight-channel body array, suggesting future areas of research that should be intensified in order to fully explore the potential of 7-T MR systems for use in clinical diagnosis. Copyright (C) 2011 John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
skeletal muscle, cartilage, brain, safety, ultrahigh-field MR, 7-T, vascular, heart
in
NMR in Biomedicine
volume
25
issue
5
pages
695 - 716
publisher
John Wiley & Sons
external identifiers
  • wos:000302617600002
  • scopus:84859646398
ISSN
0952-3480
DOI
10.1002/nbm.1794
language
English
LU publication?
yes
id
cc71544e-c947-45ba-97f9-a966facecd55 (old id 2570952)
date added to LUP
2012-06-01 08:53:21
date last changed
2017-11-19 03:17:45
@article{cc71544e-c947-45ba-97f9-a966facecd55,
  abstract     = {Over 20?000 MR systems are currently installed worldwide and, although the majority operate at magnetic fields of 1.5?T and below (i.e. about 70%), experience with 3-T (in high-field clinical diagnostic imaging and research) and 7-T (research only) human MR scanners points to a future in functional and metabolic MR diagnostics. Complementary to previous studies, this review attempts to provide an overview of ultrahigh-field MR research with special emphasis on emerging clinical applications at 7?T. We provide a short summary of the technical development and the current status of installed MR systems. The advantages and challenges of ultrahigh-field MRI and MRS are discussed with special emphasis on radiofrequency inhomogeneity, relaxation times, signal-to-noise improvements, susceptibility effects, chemical shifts, specific absorption rate and other safety issues. In terms of applications, we focus on the topics most likely to gain significantly from 7-T MR, i.e. brain imaging and spectroscopy and musculoskeletal imaging, but also body imaging, which is particularly challenging. Examples are given to demonstrate the advantages of susceptibility-weighted imaging, time-of-flight MR angiography, high-resolution functional MRI, 1H and 31P MRSI in the human brain, sodium and functional imaging of cartilage and the first results (and artefacts) using an eight-channel body array, suggesting future areas of research that should be intensified in order to fully explore the potential of 7-T MR systems for use in clinical diagnosis. Copyright (C) 2011 John Wiley & Sons, Ltd.},
  author       = {Moser, Ewald and Ståhlberg, Freddy and Ladd, Mark E. and Trattnig, Siegfried},
  issn         = {0952-3480},
  keyword      = {skeletal muscle,cartilage,brain,safety,ultrahigh-field MR,7-T,vascular,heart},
  language     = {eng},
  number       = {5},
  pages        = {695--716},
  publisher    = {John Wiley & Sons},
  series       = {NMR in Biomedicine},
  title        = {7-T MR-from research to clinical applications?},
  url          = {http://dx.doi.org/10.1002/nbm.1794},
  volume       = {25},
  year         = {2012},
}