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Accuracy and Precision of Radioactivity Quantification in Nuclear Medicine Images

Frey, Eric C.; Humm, John L. and Ljungberg, Michael LU (2012) In Seminars in Nuclear Medicine 42(3). p.208-218
Abstract
The ability to reliably quantify activity in nuclear medicine has a number of increasingly important applications. Dosimetry for targeted therapy treatment planning or for approval of new imaging agents requires accurate estimation of the activity in organs, tumors, or voxels at several imaging time points. Another important application is the use of quantitative metrics derived from images, such as the standard uptake value commonly used in positron emission tomography (PET), to diagnose and follow treatment of tumors. These measures require quantification of organ or tumor activities in nuclear medicine images. However, there are a number of physical, patient, and technical factors that limit the quantitative reliability of nuclear... (More)
The ability to reliably quantify activity in nuclear medicine has a number of increasingly important applications. Dosimetry for targeted therapy treatment planning or for approval of new imaging agents requires accurate estimation of the activity in organs, tumors, or voxels at several imaging time points. Another important application is the use of quantitative metrics derived from images, such as the standard uptake value commonly used in positron emission tomography (PET), to diagnose and follow treatment of tumors. These measures require quantification of organ or tumor activities in nuclear medicine images. However, there are a number of physical, patient, and technical factors that limit the quantitative reliability of nuclear medicine images. There have been a large number of improvements in instrumentation, including the development of hybrid single-photon emission computed tomography/computed tomography and PET/computed tomography systems, and reconstruction methods, including the use of statistical iterative reconstruction methods, which have substantially improved the ability to obtain reliable quantitative information from planar, single-photon emission computed tomography, and PET images. Semin Nucl Med 42:208-218 (C) 2012 Elsevier Inc. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Seminars in Nuclear Medicine
volume
42
issue
3
pages
208 - 218
publisher
Elsevier
external identifiers
  • wos:000302757600008
  • scopus:84859355266
ISSN
0001-2998
DOI
10.1053/j.semnuclmed.2011.11.003
language
English
LU publication?
yes
id
a0311438-08ca-4cb3-b719-a39012ed1862 (old id 2570994)
date added to LUP
2012-06-01 08:53:08
date last changed
2017-11-19 03:45:10
@article{a0311438-08ca-4cb3-b719-a39012ed1862,
  abstract     = {The ability to reliably quantify activity in nuclear medicine has a number of increasingly important applications. Dosimetry for targeted therapy treatment planning or for approval of new imaging agents requires accurate estimation of the activity in organs, tumors, or voxels at several imaging time points. Another important application is the use of quantitative metrics derived from images, such as the standard uptake value commonly used in positron emission tomography (PET), to diagnose and follow treatment of tumors. These measures require quantification of organ or tumor activities in nuclear medicine images. However, there are a number of physical, patient, and technical factors that limit the quantitative reliability of nuclear medicine images. There have been a large number of improvements in instrumentation, including the development of hybrid single-photon emission computed tomography/computed tomography and PET/computed tomography systems, and reconstruction methods, including the use of statistical iterative reconstruction methods, which have substantially improved the ability to obtain reliable quantitative information from planar, single-photon emission computed tomography, and PET images. Semin Nucl Med 42:208-218 (C) 2012 Elsevier Inc. All rights reserved.},
  author       = {Frey, Eric C. and Humm, John L. and Ljungberg, Michael},
  issn         = {0001-2998},
  language     = {eng},
  number       = {3},
  pages        = {208--218},
  publisher    = {Elsevier},
  series       = {Seminars in Nuclear Medicine},
  title        = {Accuracy and Precision of Radioactivity Quantification in Nuclear Medicine Images},
  url          = {http://dx.doi.org/10.1053/j.semnuclmed.2011.11.003},
  volume       = {42},
  year         = {2012},
}