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Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer

Andersson, Kristin LU ; Michael, Kristina M.; Luostarinen, Tapio; Waterboer, Tim; Gislefoss, Randi; Hakulinen, Timo; Forslund, Ola LU ; Pawlita, Michael and Dillner, Joakim LU (2012) In American Journal of Epidemiology 175(7). p.685-695
Abstract
Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-2003) and the Janus Biobank (1973-2003) in Norway, containing samples from 850,000 donors, were searched for incident skin cancer for up to 30 years using registry linkages. Altogether, 2,623 donors with samples taken before diagnosis of SCC or basal cell carcinoma (BCC) of the skin were identified. Prediagnostic samples and samples from 2,623 matched controls were tested for antibodies against 33 types of HPV. Baseline... (More)
Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-2003) and the Janus Biobank (1973-2003) in Norway, containing samples from 850,000 donors, were searched for incident skin cancer for up to 30 years using registry linkages. Altogether, 2,623 donors with samples taken before diagnosis of SCC or basal cell carcinoma (BCC) of the skin were identified. Prediagnostic samples and samples from 2,623 matched controls were tested for antibodies against 33 types of HPV. Baseline seropositivity to HPV types in genus beta species 2 was associated with SCC risk (odds ratio = 1.3, 95% confidence interval: 1.1, 1.7); this was also the case for samples taken more than 18 years before diagnosis (odds ratio = 1.8, 95% confidence interval: 1.1, 2.8). Type-specific persistent seropositivity entailed elevated point estimates for SCC risk for 29 HPV types and decreased point estimates for only 3 types. After multiple hypothesis adjustment, HPV 76 was significantly associated with SCC risk and HPV 9 with BCC risk. In summary, seropositivity for certain HPV types was associated with an increased risk for future development of SCC and BCC. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
beta papillomavirus, DNA tumor viruses, human papillomavirus
in
American Journal of Epidemiology
volume
175
issue
7
pages
685 - 695
publisher
Oxford University Press
external identifiers
  • wos:000302483500013
  • scopus:84859486629
ISSN
0002-9262
DOI
10.1093/aje/kwr373
language
English
LU publication?
yes
id
bc32d443-fe0c-4f44-8550-bc11fdea06e9 (old id 2574791)
date added to LUP
2012-06-01 08:57:35
date last changed
2017-02-12 03:03:09
@article{bc32d443-fe0c-4f44-8550-bc11fdea06e9,
  abstract     = {Cutaneous human papillomaviruses (HPVs) have been associated with squamous cell carcinoma (SCC) in case-control studies, but there are limited data from prospective studies assessing whether virus exposure predicts risk of future cancer development. Two major biobanks, the Southern Sweden Microbiology Biobank (1971-2003) and the Janus Biobank (1973-2003) in Norway, containing samples from 850,000 donors, were searched for incident skin cancer for up to 30 years using registry linkages. Altogether, 2,623 donors with samples taken before diagnosis of SCC or basal cell carcinoma (BCC) of the skin were identified. Prediagnostic samples and samples from 2,623 matched controls were tested for antibodies against 33 types of HPV. Baseline seropositivity to HPV types in genus beta species 2 was associated with SCC risk (odds ratio = 1.3, 95% confidence interval: 1.1, 1.7); this was also the case for samples taken more than 18 years before diagnosis (odds ratio = 1.8, 95% confidence interval: 1.1, 2.8). Type-specific persistent seropositivity entailed elevated point estimates for SCC risk for 29 HPV types and decreased point estimates for only 3 types. After multiple hypothesis adjustment, HPV 76 was significantly associated with SCC risk and HPV 9 with BCC risk. In summary, seropositivity for certain HPV types was associated with an increased risk for future development of SCC and BCC.},
  author       = {Andersson, Kristin and Michael, Kristina M. and Luostarinen, Tapio and Waterboer, Tim and Gislefoss, Randi and Hakulinen, Timo and Forslund, Ola and Pawlita, Michael and Dillner, Joakim},
  issn         = {0002-9262},
  keyword      = {beta papillomavirus,DNA tumor viruses,human papillomavirus},
  language     = {eng},
  number       = {7},
  pages        = {685--695},
  publisher    = {Oxford University Press},
  series       = {American Journal of Epidemiology},
  title        = {Prospective Study of Human Papillomavirus Seropositivity and Risk of Nonmelanoma Skin Cancer},
  url          = {http://dx.doi.org/10.1093/aje/kwr373},
  volume       = {175},
  year         = {2012},
}