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Within-Family Transmission of Alcohol Use Disorder in Parent-Offspring, Sibling, and Cousin Pairs : A Contagion Model

Kendler, Kenneth S. ; Ohlsson, Henrik LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2020) In The Journal of nervous and mental disease 208(9). p.637-645
Abstract

To determine whether alcohol use disorder (AUD) is transmitted within families as predicted by contagion, we examined parent-offspring, siblings, and cousin pairs ascertained from Swedish registries with a primary case with AUD. Our outcome variable was AUD registration in at-risk secondary cases. In offspring, risks for AUD registration in the 3 years after a parental index registration residing in the same household, neighborhood, or municipality increased by 1.6%, -0.5%, and 0.3%, respectively. For siblings of sibling index cases, parallel results were 3.2%, 1.2%, and 0.3%. For cousins of cousin index cases, no excess risk was seen for those residing in the same neighborhood or municipality. In siblings, AUD transmission was stronger... (More)

To determine whether alcohol use disorder (AUD) is transmitted within families as predicted by contagion, we examined parent-offspring, siblings, and cousin pairs ascertained from Swedish registries with a primary case with AUD. Our outcome variable was AUD registration in at-risk secondary cases. In offspring, risks for AUD registration in the 3 years after a parental index registration residing in the same household, neighborhood, or municipality increased by 1.6%, -0.5%, and 0.3%, respectively. For siblings of sibling index cases, parallel results were 3.2%, 1.2%, and 0.3%. For cousins of cousin index cases, no excess risk was seen for those residing in the same neighborhood or municipality. In siblings, AUD transmission was stronger in same versus opposite sex pairs and from older to younger versus younger to older siblings. These results support the hypothesis that AUD is transmitted among close family relationships and over limited geographical distances by a temporally dynamic contagion model.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
The Journal of nervous and mental disease
volume
208
issue
9
pages
9 pages
publisher
Wolters Kluwer
external identifiers
  • pmid:32502073
  • scopus:85090169925
ISSN
0022-3018
DOI
10.1097/NMD.0000000000001190
language
English
LU publication?
yes
id
257a2fc3-bfec-49f5-929d-52496ddb097a
date added to LUP
2020-09-25 10:10:50
date last changed
2024-06-12 21:37:27
@article{257a2fc3-bfec-49f5-929d-52496ddb097a,
  abstract     = {{<p>To determine whether alcohol use disorder (AUD) is transmitted within families as predicted by contagion, we examined parent-offspring, siblings, and cousin pairs ascertained from Swedish registries with a primary case with AUD. Our outcome variable was AUD registration in at-risk secondary cases. In offspring, risks for AUD registration in the 3 years after a parental index registration residing in the same household, neighborhood, or municipality increased by 1.6%, -0.5%, and 0.3%, respectively. For siblings of sibling index cases, parallel results were 3.2%, 1.2%, and 0.3%. For cousins of cousin index cases, no excess risk was seen for those residing in the same neighborhood or municipality. In siblings, AUD transmission was stronger in same versus opposite sex pairs and from older to younger versus younger to older siblings. These results support the hypothesis that AUD is transmitted among close family relationships and over limited geographical distances by a temporally dynamic contagion model.</p>}},
  author       = {{Kendler, Kenneth S. and Ohlsson, Henrik and Sundquist, Jan and Sundquist, Kristina}},
  issn         = {{0022-3018}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{637--645}},
  publisher    = {{Wolters Kluwer}},
  series       = {{The Journal of nervous and mental disease}},
  title        = {{Within-Family Transmission of Alcohol Use Disorder in Parent-Offspring, Sibling, and Cousin Pairs : A Contagion Model}},
  url          = {{http://dx.doi.org/10.1097/NMD.0000000000001190}},
  doi          = {{10.1097/NMD.0000000000001190}},
  volume       = {{208}},
  year         = {{2020}},
}