Diffusion Tensor Imaging of Normal-Appearing White Matter as Biomarker for Radiation-Induced Late Delayed Cognitive Decline
(2012) In International Journal of Radiation Oncology, Biology, Physics 82(5). p.2033-2040- Abstract
- Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neuro-cognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal... (More)
- Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neuro-cognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal diffusivity (lambda(parallel to)) decreased and perpendicular diffusivity (lambda(perpendicular to)) increased after RT, with early changes correlating to later changes (p < .05). The radiation dose correlated with an increase in cingulum lambda(perpendicular to) at 3 weeks, and patients with >50% of cingula volume receiving >12 Gy had a greater increase in lambda(perpendicular to) at 3 and 6 weeks (p < .05). The post-RT changes in verbal recall scores correlated linearly with the late changes in cingulum lambda(parallel to) (30 weeks, p < .02). Using receiver operating characteristic curves, early cingulum lambda(parallel to) changes predicted for post-RT changes in verbal recall scores (3 and 6 weeks, p < .05). The neurocognitive test scores correlated significantly with the quality-of-life survey results. Conclusions: The correlation between early diffusivity changes in the parahippocampal cingulum and the late decline in verbal recall suggests that diffusion tensor imaging might be useful as a biomarker for predicting late delayed cognitive decline. (C) 2012 Elsevier Inc. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2587640
- author
- Chapman, Christopher H. ; Nagesh, Vijaya ; Sundgren, Pia LU ; Buchtel, Henry ; Chenevert, Thomas L. ; Junck, Larry ; Lawrence, Theodore S. ; Tsien, Christina I. and Cao, Yue
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Diffusion tensor imaging, Neurocognitive function, Late-delayed effects, Biomarker, Quality of life
- in
- International Journal of Radiation Oncology, Biology, Physics
- volume
- 82
- issue
- 5
- pages
- 2033 - 2040
- publisher
- Elsevier
- external identifiers
-
- wos:000301891300083
- scopus:84858708942
- pmid:21570218
- ISSN
- 0360-3016
- DOI
- 10.1016/j.ijrobp.2011.01.068
- language
- English
- LU publication?
- yes
- id
- 7e15e2a2-c181-45f9-9af5-6bf0c73491e2 (old id 2587640)
- date added to LUP
- 2016-04-01 11:03:07
- date last changed
- 2022-04-12 19:59:20
@article{7e15e2a2-c181-45f9-9af5-6bf0c73491e2, abstract = {{Purpose: To determine whether early assessment of cerebral white matter degradation can predict late delayed cognitive decline after radiotherapy (RT). Methods and Materials: Ten patients undergoing conformal fractionated brain RT participated in a prospective diffusion tensor magnetic resonance imaging study. Magnetic resonance imaging studies were acquired before RT, at 3 and 6 weeks during RT, and 10, 30, and 78 weeks after starting RT. The diffusivity variables in the parahippocampal cingulum bundle and temporal lobe white matter were computed. A quality-of-life survey and neuro-cognitive function tests were administered before and after RT at the magnetic resonance imaging follow-up visits. Results: In both structures, longitudinal diffusivity (lambda(parallel to)) decreased and perpendicular diffusivity (lambda(perpendicular to)) increased after RT, with early changes correlating to later changes (p < .05). The radiation dose correlated with an increase in cingulum lambda(perpendicular to) at 3 weeks, and patients with >50% of cingula volume receiving >12 Gy had a greater increase in lambda(perpendicular to) at 3 and 6 weeks (p < .05). The post-RT changes in verbal recall scores correlated linearly with the late changes in cingulum lambda(parallel to) (30 weeks, p < .02). Using receiver operating characteristic curves, early cingulum lambda(parallel to) changes predicted for post-RT changes in verbal recall scores (3 and 6 weeks, p < .05). The neurocognitive test scores correlated significantly with the quality-of-life survey results. Conclusions: The correlation between early diffusivity changes in the parahippocampal cingulum and the late decline in verbal recall suggests that diffusion tensor imaging might be useful as a biomarker for predicting late delayed cognitive decline. (C) 2012 Elsevier Inc.}}, author = {{Chapman, Christopher H. and Nagesh, Vijaya and Sundgren, Pia and Buchtel, Henry and Chenevert, Thomas L. and Junck, Larry and Lawrence, Theodore S. and Tsien, Christina I. and Cao, Yue}}, issn = {{0360-3016}}, keywords = {{Diffusion tensor imaging; Neurocognitive function; Late-delayed effects; Biomarker; Quality of life}}, language = {{eng}}, number = {{5}}, pages = {{2033--2040}}, publisher = {{Elsevier}}, series = {{International Journal of Radiation Oncology, Biology, Physics}}, title = {{Diffusion Tensor Imaging of Normal-Appearing White Matter as Biomarker for Radiation-Induced Late Delayed Cognitive Decline}}, url = {{http://dx.doi.org/10.1016/j.ijrobp.2011.01.068}}, doi = {{10.1016/j.ijrobp.2011.01.068}}, volume = {{82}}, year = {{2012}}, }