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Molecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence

Rohde, Manfred; Talay, Susanne R. and Rasmussen, Magnus LU (2012) In Microbes and Infection 14(4). p.329-334
Abstract
Streptococcus dysgalactiae subsp. equisimilis (SDSE) can cause recurrent bacteremic infection. We have characterized novel virulence properties of an SDSE isolate of type stG485.0 that caused severe sepsis three times in a patient despite that he had opsonizing antibodies to the isolate. An infected aortic aneurysm was suspected to be the focus for the persisting bacteria. For the first time we show that this SDSE isolate, as well as other invasive SDSE isolates, aggregate human platelets and efficiently internalize into human endothelial cells. These properties may aid SDSE to persist and could explain the tendency of SDSE to cause recurrent bacteremia. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Recurrent bacteremia, Intravascular persistence, Internalization, Platelet aggregation
in
Microbes and Infection
volume
14
issue
4
pages
329 - 334
publisher
Elsevier
external identifiers
  • wos:000302428300005
  • scopus:84857994314
ISSN
1769-714X
DOI
10.1016/j.micinf.2011.10.008
language
English
LU publication?
yes
id
bf8038b4-7fb0-4bff-a1c1-d4fbdc553b6c (old id 2587772)
date added to LUP
2012-05-29 13:32:12
date last changed
2017-09-24 03:12:30
@article{bf8038b4-7fb0-4bff-a1c1-d4fbdc553b6c,
  abstract     = {Streptococcus dysgalactiae subsp. equisimilis (SDSE) can cause recurrent bacteremic infection. We have characterized novel virulence properties of an SDSE isolate of type stG485.0 that caused severe sepsis three times in a patient despite that he had opsonizing antibodies to the isolate. An infected aortic aneurysm was suspected to be the focus for the persisting bacteria. For the first time we show that this SDSE isolate, as well as other invasive SDSE isolates, aggregate human platelets and efficiently internalize into human endothelial cells. These properties may aid SDSE to persist and could explain the tendency of SDSE to cause recurrent bacteremia. (C) 2011 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.},
  author       = {Rohde, Manfred and Talay, Susanne R. and Rasmussen, Magnus},
  issn         = {1769-714X},
  keyword      = {Recurrent bacteremia,Intravascular persistence,Internalization,Platelet aggregation},
  language     = {eng},
  number       = {4},
  pages        = {329--334},
  publisher    = {Elsevier},
  series       = {Microbes and Infection},
  title        = {Molecular mechanisms of Streptococcus dysgalactiae subsp equisimilis enabling intravascular persistence},
  url          = {http://dx.doi.org/10.1016/j.micinf.2011.10.008},
  volume       = {14},
  year         = {2012},
}