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Familial risk and familial survival in prostate cancer

Hemminki, Kari LU (2012) In World Journal of Urology 30(2). p.143-148
Abstract
The Swedish Family-Cancer Database has been the major source of population-based prospective data on familial risks on most cancers, including prostate cancer. In the present review, I focus on three lines of family studies with novel results. The covered studies originate from the same database with publication dates spanning a period of somewhat over 3 years. Age-specific hazard ratios (HRs) of incident prostate cancer and fatal prostate cancer were determined according to the number of affected relatives. Cumulative risks for incidence and death were calculated for the various types of families. Finally, data on the familial association of prostate cancer with some other cancers were reviewed. If the father had prostate cancer, the HR... (More)
The Swedish Family-Cancer Database has been the major source of population-based prospective data on familial risks on most cancers, including prostate cancer. In the present review, I focus on three lines of family studies with novel results. The covered studies originate from the same database with publication dates spanning a period of somewhat over 3 years. Age-specific hazard ratios (HRs) of incident prostate cancer and fatal prostate cancer were determined according to the number of affected relatives. Cumulative risks for incidence and death were calculated for the various types of families. Finally, data on the familial association of prostate cancer with some other cancers were reviewed. If the father had prostate cancer, the HR for sons was 2.1 and it increased to 17.7 when three brothers were affected. The highest HR (23) was observed for men before age 60 years with three affected brothers. The patterns for fatal familial prostate cancer were similar. Other reviewed sets of data showed evidence for the familial concordance of good and poor survival in prostate cancer. Familial risks were somewhat higher for fatal than for incident prostate cancer, suggesting that fatal prostate cancers may be a genetic subgroup. Considering the high familial risks in fatal prostate cancer, family history remains an important prognostic piece of information useful for clinical genetic counseling. Obviously, preventive measures for at-risk men are needed but these are beyond the present paper. Starting screening before any prostate cancers are diagnosed in a family appears counterproductive. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Familial cancers, Survival, Genes, Clinical counseling
in
World Journal of Urology
volume
30
issue
2
pages
143 - 148
publisher
Springer
external identifiers
  • wos:000302406000004
  • scopus:84859438311
ISSN
1433-8726
DOI
10.1007/s00345-011-0801-1
language
English
LU publication?
yes
id
f071ab37-a2ec-4021-aea8-11b044473104 (old id 2591029)
date added to LUP
2012-06-01 09:39:42
date last changed
2017-08-27 04:51:53
@article{f071ab37-a2ec-4021-aea8-11b044473104,
  abstract     = {The Swedish Family-Cancer Database has been the major source of population-based prospective data on familial risks on most cancers, including prostate cancer. In the present review, I focus on three lines of family studies with novel results. The covered studies originate from the same database with publication dates spanning a period of somewhat over 3 years. Age-specific hazard ratios (HRs) of incident prostate cancer and fatal prostate cancer were determined according to the number of affected relatives. Cumulative risks for incidence and death were calculated for the various types of families. Finally, data on the familial association of prostate cancer with some other cancers were reviewed. If the father had prostate cancer, the HR for sons was 2.1 and it increased to 17.7 when three brothers were affected. The highest HR (23) was observed for men before age 60 years with three affected brothers. The patterns for fatal familial prostate cancer were similar. Other reviewed sets of data showed evidence for the familial concordance of good and poor survival in prostate cancer. Familial risks were somewhat higher for fatal than for incident prostate cancer, suggesting that fatal prostate cancers may be a genetic subgroup. Considering the high familial risks in fatal prostate cancer, family history remains an important prognostic piece of information useful for clinical genetic counseling. Obviously, preventive measures for at-risk men are needed but these are beyond the present paper. Starting screening before any prostate cancers are diagnosed in a family appears counterproductive.},
  author       = {Hemminki, Kari},
  issn         = {1433-8726},
  keyword      = {Familial cancers,Survival,Genes,Clinical counseling},
  language     = {eng},
  number       = {2},
  pages        = {143--148},
  publisher    = {Springer},
  series       = {World Journal of Urology},
  title        = {Familial risk and familial survival in prostate cancer},
  url          = {http://dx.doi.org/10.1007/s00345-011-0801-1},
  volume       = {30},
  year         = {2012},
}