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Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances

Pifferi, A; Swartling, Johannes LU ; Chikoidze, E; Torricelli, A; Taroni, P; Bassi, A; Andersson-Engels, Stefan LU and Cubeddu, R (2004) In Journal of Biomedical Optics 9(6). p.1143-1151
Abstract
The first, to our knowledge, in-vivo broadband spectro-scopic characterization of breast tissue using different interfiber distances as well as transmittance measurements is presented. Absorption and scattering properties are measured on six healthy subjects, using time-resolved diffuse spectroscopy and an inverse model based on the diffusion equation. Waveiength-tunable picosecond-pulse-lasers and time-correlated single-photon counting detection are employed, enabling fully spectroscopic measurements in the range 610 to 1040 nm. Characterization of the absorption and reduced scattering coefficients of breast tissue is made with the aim of investigating individual variations, as well as variations due to different measurement geometries.... (More)
The first, to our knowledge, in-vivo broadband spectro-scopic characterization of breast tissue using different interfiber distances as well as transmittance measurements is presented. Absorption and scattering properties are measured on six healthy subjects, using time-resolved diffuse spectroscopy and an inverse model based on the diffusion equation. Waveiength-tunable picosecond-pulse-lasers and time-correlated single-photon counting detection are employed, enabling fully spectroscopic measurements in the range 610 to 1040 nm. Characterization of the absorption and reduced scattering coefficients of breast tissue is made with the aim of investigating individual variations, as well as variations due to different measurement geometries. Diffuse reflectance measurements at different interfiber distances (2, 3, and 4 cm) are performed, as well as measurements in transmittance mode, meaning that different sampling volumes are involved. The results show a large variation in the absorption and scattering properties depending on the subject, correlating mainly with the water versus lipid content of the breast. Intra-subject variations, due to different interfiber distances or transmittance modes, correlate with the known structures of the breast, but these variations are small compared to the subject-to-subject variation. The intrasubject variations are larger for the scattering data than the absorption data; this is consistent with different spatial localization of the measurements of these parameters, which is explained by the photon migration theory. (C) 2004 Society of Photo-Optical Instrumentation Engineers. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
optical, absorption, time-resolved spectroscopy, scattering, mammography, breast
in
Journal of Biomedical Optics
volume
9
issue
6
pages
1143 - 1151
publisher
Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society
external identifiers
  • wos:000225697400006
  • scopus:12844285785
ISSN
1083-3668
DOI
10.1117/1.1802171
language
English
LU publication?
yes
id
66025ed9-68dc-40bf-a2c6-5d53738e4639 (old id 259226)
date added to LUP
2007-10-30 07:21:32
date last changed
2017-08-27 04:11:29
@article{66025ed9-68dc-40bf-a2c6-5d53738e4639,
  abstract     = {The first, to our knowledge, in-vivo broadband spectro-scopic characterization of breast tissue using different interfiber distances as well as transmittance measurements is presented. Absorption and scattering properties are measured on six healthy subjects, using time-resolved diffuse spectroscopy and an inverse model based on the diffusion equation. Waveiength-tunable picosecond-pulse-lasers and time-correlated single-photon counting detection are employed, enabling fully spectroscopic measurements in the range 610 to 1040 nm. Characterization of the absorption and reduced scattering coefficients of breast tissue is made with the aim of investigating individual variations, as well as variations due to different measurement geometries. Diffuse reflectance measurements at different interfiber distances (2, 3, and 4 cm) are performed, as well as measurements in transmittance mode, meaning that different sampling volumes are involved. The results show a large variation in the absorption and scattering properties depending on the subject, correlating mainly with the water versus lipid content of the breast. Intra-subject variations, due to different interfiber distances or transmittance modes, correlate with the known structures of the breast, but these variations are small compared to the subject-to-subject variation. The intrasubject variations are larger for the scattering data than the absorption data; this is consistent with different spatial localization of the measurements of these parameters, which is explained by the photon migration theory. (C) 2004 Society of Photo-Optical Instrumentation Engineers.},
  author       = {Pifferi, A and Swartling, Johannes and Chikoidze, E and Torricelli, A and Taroni, P and Bassi, A and Andersson-Engels, Stefan and Cubeddu, R},
  issn         = {1083-3668},
  keyword      = {optical,absorption,time-resolved spectroscopy,scattering,mammography,breast},
  language     = {eng},
  number       = {6},
  pages        = {1143--1151},
  publisher    = {Published by SPIE--the International Society for Optical Engineering in cooperation with International Biomedical Optics Society},
  series       = {Journal of Biomedical Optics},
  title        = {Spectroscopic time-resolved diffuse reflectance and transmittance measurements of the female breast at different interfiber distances},
  url          = {http://dx.doi.org/10.1117/1.1802171},
  volume       = {9},
  year         = {2004},
}