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Familial Aggregation of Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia with Solid Tumors and Myeloid Malignancies

Kristinsson, Sigurdur Y.; Goldin, Lynn R.; Turesson, Ingemar LU ; Bjorkholm, Magnus and Landgren, Ola (2012) In Acta Haematologica 127(3). p.173-177
Abstract
Lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year. Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients. Copyright... (More)
Lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year. Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients. Copyright (C) 2012 S. Karger AG, Basel (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Autoimmunity, Familial aggregation, Hematological malignancies, Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia, Monoclonal, gammopathy of undetermined significance, Solid tumors, Susceptibility
in
Acta Haematologica
volume
127
issue
3
pages
173 - 177
publisher
Karger
external identifiers
  • wos:000302205200009
  • scopus:84856588322
ISSN
1421-9662
DOI
10.1159/000335618
language
English
LU publication?
yes
id
e57e243d-9ab3-4d9d-8fd0-ae6b5ed7fcda (old id 2594577)
date added to LUP
2012-06-01 09:38:01
date last changed
2017-01-01 03:07:33
@article{e57e243d-9ab3-4d9d-8fd0-ae6b5ed7fcda,
  abstract     = {Lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) is a B-cell disorder resulting from the accumulation, predominantly in the bone marrow, of clonally related lymphoplasmacytic cells. LPL/WM is a very rare disease, with an incidence rate of 3-4 cases per million people per year. Currently, the causes of LPL/WM are poorly understood; however, there are emerging data to support a role for immune-related factors in the pathogenesis of LPL/WM. In addition, data show that genetic factors are of importance in the etiology of LPL/WM. In this paper, we will review the current knowledge about familiality of LPL/WM and provide novel data on solid tumors and myeloid malignancies in first-degree relatives of LPL/WM patients. Copyright (C) 2012 S. Karger AG, Basel},
  author       = {Kristinsson, Sigurdur Y. and Goldin, Lynn R. and Turesson, Ingemar and Bjorkholm, Magnus and Landgren, Ola},
  issn         = {1421-9662},
  keyword      = {Autoimmunity,Familial aggregation,Hematological malignancies,Lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia,Monoclonal,gammopathy of undetermined significance,Solid tumors,Susceptibility},
  language     = {eng},
  number       = {3},
  pages        = {173--177},
  publisher    = {Karger},
  series       = {Acta Haematologica},
  title        = {Familial Aggregation of Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia with Solid Tumors and Myeloid Malignancies},
  url          = {http://dx.doi.org/10.1159/000335618},
  volume       = {127},
  year         = {2012},
}