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Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate

Andersen, Claus Yding; Bungum, Leif LU ; Andersen, Anders Nyboe and Humaidan, Peter (2011) In Reproductive BioMedicine Online 23(2). p.187-195
Abstract
Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day of HCG administration in 475 patients who underwent IVF/intracytoplasmic sperm injection treatment following ovarian stimulation with gonadotrophin-releasing hormone (GnRH) agonist and recombinant FSH with or without rLH administration from day 6 of stimulation. There was no significant association between the late-follicular-phase progesterone... (More)
Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day of HCG administration in 475 patients who underwent IVF/intracytoplasmic sperm injection treatment following ovarian stimulation with gonadotrophin-releasing hormone (GnRH) agonist and recombinant FSH with or without rLH administration from day 6 of stimulation. There was no significant association between the late-follicular-phase progesterone concentration and the clinical pregnancy rate. However, progesterone concentration was strongly associated with the number of follicles and retrieved oocytes. Late-follicular-phase LH concentration also showed a significant positive association with progesterone concentration (P = 0.018). Administration of rLH during ovarian stimulation did not affect progesterone concentration. The present study does not support an association between progesterone concentration on the day of HCG administration and the probability of clinical pregnancy in women undergoing ovarian stimulation with GnRH agonists and gonadotrophins for assisted reproduction treatment. Instead, late-follicular-phase progesterone concentration appears to be governed by the number of preovulatory follicles and LH concentration. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
keywords
ovarian stimulation, pregnancy outcome, progesterone elevation
in
Reproductive BioMedicine Online
volume
23
issue
2
pages
187 - 195
publisher
Reproductive Healthcare Ltd
external identifiers
  • wos:000303044500005
  • scopus:79961173173
ISSN
1472-6491
DOI
10.1016/j.rbmo.2011.04.003
language
English
LU publication?
yes
id
e88436bf-fa43-47ae-861f-08b0937c2545 (old id 2594759)
date added to LUP
2012-06-01 09:39:36
date last changed
2017-09-10 03:22:26
@article{e88436bf-fa43-47ae-861f-08b0937c2545,
  abstract     = {Using data from a large prospective randomized controlled trial that evaluated the effect of recombinant LH (rLH) co-administration for ovarian stimulation, the present study assessed whether progesterone concentration on the day of human chorionic gonadotrophin (HCG) administration was associated with pregnancy outcome. Progesterone concentration was measured on stimulation day 1 and on the day of HCG administration in 475 patients who underwent IVF/intracytoplasmic sperm injection treatment following ovarian stimulation with gonadotrophin-releasing hormone (GnRH) agonist and recombinant FSH with or without rLH administration from day 6 of stimulation. There was no significant association between the late-follicular-phase progesterone concentration and the clinical pregnancy rate. However, progesterone concentration was strongly associated with the number of follicles and retrieved oocytes. Late-follicular-phase LH concentration also showed a significant positive association with progesterone concentration (P = 0.018). Administration of rLH during ovarian stimulation did not affect progesterone concentration. The present study does not support an association between progesterone concentration on the day of HCG administration and the probability of clinical pregnancy in women undergoing ovarian stimulation with GnRH agonists and gonadotrophins for assisted reproduction treatment. Instead, late-follicular-phase progesterone concentration appears to be governed by the number of preovulatory follicles and LH concentration. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.},
  author       = {Andersen, Claus Yding and Bungum, Leif and Andersen, Anders Nyboe and Humaidan, Peter},
  issn         = {1472-6491},
  keyword      = {ovarian stimulation,pregnancy outcome,progesterone elevation},
  language     = {eng},
  number       = {2},
  pages        = {187--195},
  publisher    = {Reproductive Healthcare Ltd},
  series       = {Reproductive BioMedicine Online},
  title        = {Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate},
  url          = {http://dx.doi.org/10.1016/j.rbmo.2011.04.003},
  volume       = {23},
  year         = {2011},
}