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Prebiotic oligosaccharides in dietetic products for infants: A commentary by the ESPGHAN committee on nutrition

Agostoni, C; Axelsson, Irene LU ; Goulet, O; Koletzko, B; Michaelsen, KF; Puntis, JWL; Rigo, J; Shamir, R; Szajewska, H and Turck, D (2004) In Journal of Pediatric Gastroenterology and Nutrition - Jpgn 39(5). p.465-473
Abstract
This article by the ESPGHAN Committee on Nutrition summarizes available information on the effects of adding prebiotic oligosaccharides to infant and follow-on formulae. Currently there are only limited studies evaluating prebiotic substances in dietetic products for infants. Although administration of prebiotic oligosaccharides has the potential to increase the total number of bifidobacteria in feces and may also soften stools, there is no published evidence of clinical benefits of adding prebiotic oligosaccharides to dietetic products for infants. Data on oligosaccharide mixtures in infant formulae do not demonstrate adverse effects, but further evaluation is recommended. Combinations and dosages in addition to those so far studied need... (More)
This article by the ESPGHAN Committee on Nutrition summarizes available information on the effects of adding prebiotic oligosaccharides to infant and follow-on formulae. Currently there are only limited studies evaluating prebiotic substances in dietetic products for infants. Although administration of prebiotic oligosaccharides has the potential to increase the total number of bifidobacteria in feces and may also soften stools, there is no published evidence of clinical benefits of adding prebiotic oligosaccharides to dietetic products for infants. Data on oligosaccharide mixtures in infant formulae do not demonstrate adverse effects, but further evaluation is recommended. Combinations and dosages in addition to those so far studied need to be fully evaluated with respect to both safety and efficacy before their use in commercial infant food products. Well-designed and carefully conducted randomized controlled trials with relevant inclusion/exclusion criteria, adequate sample sizes and validated clinical outcome measures are needed both in preterm and term infants. Future trials should define optimal quantity and types of oligosaccharides with prebiotic function, optimal dosages and duration of intake, short and long term benefits and safety. At the present time, therefore, the Committee takes the view that no general recommendation on the use of oligosaccharide supplementation in infancy as a prophylactic or therapeutic measure can be made. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prebiotics, infant nutrition, infant formula
in
Journal of Pediatric Gastroenterology and Nutrition - Jpgn
volume
39
issue
5
pages
465 - 473
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:15572882
  • wos:000225507400003
  • scopus:20144387171
ISSN
1536-4801
language
English
LU publication?
yes
id
43d59446-df43-4f38-8f14-c5177cccb1d1 (old id 259580)
date added to LUP
2007-08-28 16:13:54
date last changed
2017-01-29 03:28:57
@article{43d59446-df43-4f38-8f14-c5177cccb1d1,
  abstract     = {This article by the ESPGHAN Committee on Nutrition summarizes available information on the effects of adding prebiotic oligosaccharides to infant and follow-on formulae. Currently there are only limited studies evaluating prebiotic substances in dietetic products for infants. Although administration of prebiotic oligosaccharides has the potential to increase the total number of bifidobacteria in feces and may also soften stools, there is no published evidence of clinical benefits of adding prebiotic oligosaccharides to dietetic products for infants. Data on oligosaccharide mixtures in infant formulae do not demonstrate adverse effects, but further evaluation is recommended. Combinations and dosages in addition to those so far studied need to be fully evaluated with respect to both safety and efficacy before their use in commercial infant food products. Well-designed and carefully conducted randomized controlled trials with relevant inclusion/exclusion criteria, adequate sample sizes and validated clinical outcome measures are needed both in preterm and term infants. Future trials should define optimal quantity and types of oligosaccharides with prebiotic function, optimal dosages and duration of intake, short and long term benefits and safety. At the present time, therefore, the Committee takes the view that no general recommendation on the use of oligosaccharide supplementation in infancy as a prophylactic or therapeutic measure can be made.},
  author       = {Agostoni, C and Axelsson, Irene and Goulet, O and Koletzko, B and Michaelsen, KF and Puntis, JWL and Rigo, J and Shamir, R and Szajewska, H and Turck, D},
  issn         = {1536-4801},
  keyword      = {prebiotics,infant nutrition,infant formula},
  language     = {eng},
  number       = {5},
  pages        = {465--473},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Pediatric Gastroenterology and Nutrition - Jpgn},
  title        = {Prebiotic oligosaccharides in dietetic products for infants: A commentary by the ESPGHAN committee on nutrition},
  volume       = {39},
  year         = {2004},
}