Autofluorescence of pigmented skin lesions using a pulsed UV laser
(2010) 7715. p.1-77151- Abstract
- We report preliminary clinical results of autofluorescence imaging of malignant and benign skin lesions, using pulsed
355 nm laser excitation with synchronized detection. The novel synchronized detection system allows high signal-tonoise
ratio to be achieved in the resulting autofluorescence signal, which may in turn produce high contrast images that
improve diagnosis, even in the presence of ambient room light. The synchronized set-up utilizes a compact, diode
pumped, pulsed UV laser at 355 nm which is coupled to a CCD camera and a liquid crystal tunable filter. The excitation
and image capture is sampled at 5 kHz and the resulting autofluorescence is captured with the liquid crystal filter... (More) - We report preliminary clinical results of autofluorescence imaging of malignant and benign skin lesions, using pulsed
355 nm laser excitation with synchronized detection. The novel synchronized detection system allows high signal-tonoise
ratio to be achieved in the resulting autofluorescence signal, which may in turn produce high contrast images that
improve diagnosis, even in the presence of ambient room light. The synchronized set-up utilizes a compact, diode
pumped, pulsed UV laser at 355 nm which is coupled to a CCD camera and a liquid crystal tunable filter. The excitation
and image capture is sampled at 5 kHz and the resulting autofluorescence is captured with the liquid crystal filter cycling
through seven wavelengths between 420 nm and 580 nm. The clinical study targets pigmented skin lesions and evaluates
the prospects of using autofluorescence as a possible means in differentiating malignant and benign skin tumors. Up to
now, sixteen patients have participated in the clinical study. The autofluorescence images, averaged over the exposure
time of one second, will be presented along with histopathological results. Initial survey of the images show good
contrast and diagnostic results show promising agreement based on the histopathological results. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2596013
- author
- organization
- publishing date
- 2010
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- autofluorescence imaging, photodynamic therapy, skin lesion, diagnostic
- host publication
- Proceedings of SPIE
- volume
- 7715
- pages
- 1 - 77151
- publisher
- SPIE
- external identifiers
-
- scopus:78751606332
- DOI
- 10.1117/12.855837
- language
- English
- LU publication?
- yes
- id
- 7d6549cd-4aad-4071-b8f0-5a27fbd5d226 (old id 2596013)
- date added to LUP
- 2016-04-04 09:52:48
- date last changed
- 2022-01-29 19:26:38
@inproceedings{7d6549cd-4aad-4071-b8f0-5a27fbd5d226,
abstract = {{We report preliminary clinical results of autofluorescence imaging of malignant and benign skin lesions, using pulsed<br/><br>
355 nm laser excitation with synchronized detection. The novel synchronized detection system allows high signal-tonoise<br/><br>
ratio to be achieved in the resulting autofluorescence signal, which may in turn produce high contrast images that<br/><br>
improve diagnosis, even in the presence of ambient room light. The synchronized set-up utilizes a compact, diode<br/><br>
pumped, pulsed UV laser at 355 nm which is coupled to a CCD camera and a liquid crystal tunable filter. The excitation<br/><br>
and image capture is sampled at 5 kHz and the resulting autofluorescence is captured with the liquid crystal filter cycling<br/><br>
through seven wavelengths between 420 nm and 580 nm. The clinical study targets pigmented skin lesions and evaluates<br/><br>
the prospects of using autofluorescence as a possible means in differentiating malignant and benign skin tumors. Up to<br/><br>
now, sixteen patients have participated in the clinical study. The autofluorescence images, averaged over the exposure<br/><br>
time of one second, will be presented along with histopathological results. Initial survey of the images show good<br/><br>
contrast and diagnostic results show promising agreement based on the histopathological results.}},
author = {{Cheng, Haynes P. H. and Svenmarker, Pontus and Xie, Haiyan and Tidemand-Lichtenberg, Peter and Jensen, Ole B. and Bendsöe, Niels and Svanberg, Katarina and Petersen, Paul Michael and Pedersen, Christian and Andersson-Engels, Stefan and Andersen, Peter E.}},
booktitle = {{Proceedings of SPIE}},
keywords = {{autofluorescence imaging; photodynamic therapy; skin lesion; diagnostic}},
language = {{eng}},
pages = {{1--77151}},
publisher = {{SPIE}},
title = {{Autofluorescence of pigmented skin lesions using a pulsed UV laser}},
url = {{https://lup.lub.lu.se/search/files/5412206/2596078.pdf}},
doi = {{10.1117/12.855837}},
volume = {{7715}},
year = {{2010}},
}